학술논문
Brief Report: Impaired CD4 T-Cell Response to Autophagy in Treated HIV-1–Infected Individuals
Document Type
Academic Journal
Author
Source
JAIDS Journal of Acquired Immune Deficiency Syndromes. Feb 01, 2017 74(2):201-205
Subject
Language
English
ISSN
1525-4135
Abstract
ABSTRACT:: Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1–infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1–treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.