학술논문
Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum
Document Type
Academic Journal
Author
Source
AIDS. Mar 30, 2008 22(6):785-787
Subject
Language
English
ISSN
0269-9370
Abstract
Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-α stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.