부산대학교 도서관

Introduction: Atrial fibrillation (AF) and atrial flutter (AFL) are the most prevalent cardiac arrhythmias. Although the incidence and disease burden have been increasing, once adjusted for age, the standardized incidence has been decreasing, reaching 57.10 per 100,000 as of 2019. This study aims to explore this epidemiological trend pertaining to the younger population which are often underrepresented in AF/AFL studies.Methods: Utilizing the Global Burden of Disease (GBD) database, we calculated the incidence and disability-adjusted life years (DALYs) of AF/AFL patients aged 15-49 years along with the age standardized rates (ASR) and annual percentage changes (APC) for the incidence and DALYs from 2010 to 2019. We also calculated these values for populations according to socio-demographic index (SDI) group, region, and gender.Result: From 2010 to 2019, the standardized incidence and DALYs of early onset AF/AFL (EOAF/AFL) had increased globally. The APC of ASR of incidence had been +0.15% (95% confidence interval (CI) 0.21%-0.08%) and the APC of ASR of DALYs had been 0.28% (95% CI 0.36%-0.21%), respectively. Women demonstrated higher APC of both ASRs of incidence (+0.45% (95% CI 0.40%-0.50%) and DALYs (+0.50% (95% CI 0.45%-0.55%) while men experienced a stable trend of ASR of incidence and declining trend of ASR of DALYs. Geographic analysis showed that Eastern Mediterranean population had the highest APCs of both ASRs of incidence (+1.53% (95% CI 0.40%-0.50%)) and DALYs (+1.61%95% CI 0.40%-0.50%)), while both ASR and DALYs declined in the United StatesConclusion: The incidence and DALYs of EOAF/AFL had been increasing globally, especially among women. However, rates differed by geographic region. For example, Eastern Mediterranean regions showed the largest increases across all age groups. In contrast, the incidence of EOAF/AFL had continued to decline in the United States. Future study is warranted to explore the geographical impact on the risk factors of AF/AFL.