학술논문
Brief Report: Accelerated Aging Influences Cardiovascular Disease Risk in Rheumatoid Arthritis
Document Type
Academic Journal
Author
Source
Arthritis & Rheumatism. Oct 01, 2013 65(10):2562-2566
Subject
Language
English
ISSN
0004-3591
Abstract
OBJECTIVE: METHODS: RESULTS: The study included 563 patients with RA without prior CVD (mean age 55 years, 72% women, and 69% seropositive [i.e., rheumatoid factor and/or anti–citrullinated protein antibody positive]). During a mean followup of 8.2 years, 98 patients developed CVD (74 seropositive and 24 seronegative), but the FRS predicted only 59.7 events (35.4 seropositive and 24.3 seronegative). The gap between observed and predicted CVD risk increased exponentially across age, and the effect of age on CVD risk in seropositive RA was nearly double its effect in the general population, with additional log(age) coefficients of 2.91 for women (P = 0.002) and 2.06 for men (P = 0.027). CONCLUSION