학술논문
Impact of Overweight and Obesity on Disease Outcome in the Pediatric Swiss Inflammatory Bowel Disease Cohort
Document Type
Academic Journal
Author
von Graffenried, Thea; Schoepfer, Alain M.; Rossel, Jean-Benoit; Greuter, Thomas; Safroneeva, Ekaterina; Godat, Sébastien; Henchoz, Sarah; Vavricka, Stephan R.; Sokollik, Christiane; Spalinger, Johannes; Braegger, Christian P.; Nydegger, Andreas; Abdelrahman, Karim; Ademi, Gentiana; Aepli, Patrick; Thomas, Amman; Anderegg, Claudia; Antonino, Anca-Teodora; Archanioti, Eva; Arrigoni, Eviano; de Jong, Diana Bakker; Balsiger, Bruno; Bastürk, Polat; Bauerfeind, Peter; Becocci, Andrea; Belli, Dominique; Bengoa, José M.; Biedermann, Luc; Binek, Janek; Blattmann, Mirjam; Boehm, Stephan; Boldanova, Tujana; Borovicka, Jan; Braegger, Christian P.; Brand, Stephan; Brügger, Lukas; Brunner, Simon; Bühr, Patrick; Burnand, Bernard; Burk, Sabine; Burri, Emanuel; Buyse, Sophie; Cao, Dahlia-Thao; Carstens, Ove; Criblez, Dominique H.; Cunningham, Sophie; D’Angelo, Fabrizia; de Saussure, Philippe; Degen, Lukas; Delarive, Joakim; Doerig, Christopher; Dora, Barbara; Drerup, Susan; Egger, Mara; El-Wafa, Ali; Engelmann, Matthias; Felley, Christian; Fliegner, Markus; Fournier, Nicolas; Fraga, Montserrat; Franc, Yannick; Frei, Pascal; Frei, Remus; Fried, Michael; Froehlich, Florian; Furlano, Raoul Ivano; Garzoni, Luca; Geyer, Martin; Girard, Laurent; Girardin, Marc; Golay, Delphine; Good, Ignaz; Bigler, Ulrike Graf; Gysi, Beat; Haarer, Johannes; Halama, Marcel; Haldemann, Janine; Heer, Pius; Heimgartner, Benjamin; Helbling, Beat; Hengstler, Peter; Herzog, Denise; Hess, Cyrill; Heyland, Klaas; Hinterleitner, Thomas; Hirschi, Claudia; Hruz, Petr; Juillerat, Pascal; Khalid-de Bakker, Carolina; Kayser, Stephan; Keller, Céline; Knellwolf, Christina; Knoblauch, Christoph; Köhler, Henrik; Koller, Rebekka; Krieger, Claudia; Künzler, Patrizia; Kusche, Rachel; Lehmann, Frank Serge; Macpherson, Andrew; Maillard, Michel H.; Manz, Michael; Marot, Astrid; Meier, Rémy; Meyenberger, Christa; Meyer, Pamela; Michetti, Pierre; Misselwitz, Benjamin; Mosler, Patrick; Mottet, Christian; Müller, Christoph; Müllhaupt, Beat; Musso, Leilla; Neagu, Michaela; Nichita, Cristina; Niess, Jan; Nydegger, Andreas; Obialo, Nicole; Ollo, Diana; Oropesa, Cassandra; Peter, Ulrich; Peternac, Daniel; Petit, Laetitia Marie; Pittet, Valérie; Pohl, Daniel; Porzner, Marc; Preissler, Claudia; Raschle, Nadia; Rentsch, Ronald; Restellini, Alexandre; Restellini, Sophie; Richterich, Jean-Pierre; Ris, Frederic; Risti, Branislav; Ritz, Marc Alain; Rogler, Gerhard; Röhrich, Nina; Rossel, Jean-Benoît; Rueger, Vanessa; Rusticeanu, Monica; Sagmeister, Markus; Saner, Gaby; Sauter, Bernhard; Sawatzki, Mikael; Scharl, Michael; Schelling, Martin; Schibli, Susanne; Schlauri, Hugo; Schluckebier, Dominique; Schmid, Daniela; Schmid, Sybille; Schnegg, Jean-François; Schoepfer, Alain; Seematter, Vivianne; Seibold, Frank; Seirafi, Mariam; Semadeni, Gian-Marco; Senning, Arne; Sokollik, Christiane; Sommer, Joachim; Spalinger, Johannes; Spangenberger, Holger; Stadler, Philippe; Staub, Peter; Staudenmann, Dominic; Stenz, Volker; Steuerwald, Michael; Straumann, Alex; Stulz, Andreas; Sulz, Michael; Tatu, Aurora; Tempia-Caliera, Michela; Thorens, Joël; Truninger, Kaspar; Tutuian, Radu; Urfer, Patrick; Vavricka, Stephan; Viani, Francesco; Vögtlin, Jürg; Von Känel, Roland; Vouillamoz, Dominique; Vulliamy, Rachel; Wiesel, Paul; Wiest, Reiner; Wöhrle, Stefanie; Zamora, Samuel; Zander, Silvan; Zeitz, Jonas; Zimmermann, Dorothee
Source
JPGN Reports. May 01, 2022 3(2):e193-e193
Subject
Language
English
ISSN
2691-171X
Abstract
OBJECTIVES:: Given the paucity of data, we aimed to assess the impact of obesity on disease activity, complications, and quality of life (QoL) in pediatric inflammatory bowel disease (IBD) patients. METHODS:: Prospective analysis of pediatric IBD patients. Patients were categorized into 4 groups according to the World Health Organization (WHO) child growth standards: obese, overweight, normal weight, and underweight. RESULTS:: Three hundred twenty-seven pediatric patients were included (146 with Crohn’s disease [CD], 181 with ulcerative colitis of whom 13 [4%] were underweight, 272 [83.2%] had normal weight, 22 [6.7%] were overweight, and 20 [6.1%] were obese). Compared with normal weight patients, obese ulcerative colitis had a significantly higher clinical but not biological disease activity nor severity. Compared with normal weight patients, overweight/obese CD patients did not have higher clinical or biological disease activity nor severity. Perianal abscesses and surgery for this purpose were more frequently observed in overweight/obese CD patients compared with normal weight controls. Overweight/obese IBD patients were similarly hospitalized in the last 12 months compared with normal weight controls. CONCLUSIONS:: Prevalence of overweight/obesity was 12.8% in pediatric IBD patients. Obesity was not associated with a decrease in disease remission rates nor an increase in the risk of complicated disease progression in IBD pediatric patients, except for the occurrence of perianal abscesses and related surgery in CD patients.