학술논문
Effects of MLC601 on Early Vascular Events in Patients After Stroke: The CHIMES Study
Document Type
Academic Journal
Author
Chen, Christopher L.H.; Venketasubramanian, Narayanaswamy; Lee, Chun Fan; Wong, K.S. Lawrence; Bousser, Marie-Germaine; Navarro, Jose C.; Gan, Herminigildo H.; Lao, Annabelle Y.; Baroque, Alejandro C., II; Lokin, Johnny; Hiyadan, John Harold B.; Sarfati, Ma. Socorro; Fangonillo, Randolph John; Ambasing, Neil; Chua, Carlos L.; San Jose, Ma. Cristina; Advincula, Joel M.; Berame, Eli John; Canete, Maria Teresa; Venketasubramanian, Narayanaswamy; Young, Sherry H.Y.; Mamauag, Marlie Jane; Tay, San San; Pande, Shrikant; Thirugnanam, Umapathi; Singh, Rajinder; Chang, Hui Meng; De Silva, Deidre Anne; Chan, Bernard P.L.; Sharma, Vijay; Luen, Teoh Hock; Poungvarin, Niphon; Muengtaweepongsa, Sombat; Towanabut, Somchai; Suwanwela, Nijasri C.; Chotickanuchit, Songkram; Chankrachang, Siwaporn; Nitinun, Samart; de Silva, H. Asita; Ranawake, Udaya; Wijekoon, Nirmala; Wong, K.S. Lawrence; Eow, Gaik Bee
Source
Stroke. Dec 01, 2013 44(12):3580-3583
Subject
Language
English
ISSN
0039-2499
Abstract
BACKGROUND AND PURPOSE—: Early vascular events are an important cause of morbidity and mortality in the first 3 months after a stroke. We aimed to investigate the effects of MLC601 on the occurrence of early vascular events within 3 months of stroke onset. METHODS—: Post hoc analysis was performed on data from subjects included in the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study, a randomized, placebo-controlled, double-blinded trial that compared MLC601 with placebo in 1099 subjects with ischemic stroke of intermediate severity in the preceding 72 hours. Early vascular events were defined as a composite of recurrent stroke, acute coronary syndrome, and vascular death occurring within 3 months of stroke onset. RESULTS—: The frequency of early vascular events during the 3-month follow-up was significantly less in the MLC601 group than in the placebo group (16 [2.9%] versus 31 events [5.6%]; risk difference=−2.7%; 95% confidence interval, −5.1% to −0.4%; P=0.025) without an increase in nonvascular deaths. Kaplan–Meier survival analysis showed a difference in the risk of vascular outcomes between the 2 groups as early as the first month after stroke (Log-rank P=0.024; hazard ratio, 0.51; 95% confidence interval, 0.28–0.93). CONCLUSIONS—: Treatment with MLC601 was associated with reduced early vascular events among subjects in the CHIMES study. The mechanisms for this effect require further study. CLINICAL TRIAL REGISTRATION—: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00554723.