학술논문
Changes in Etiology of Invasive Bacterial Infections in Infants Under 3 Months of Age in Korea, 2006–2020
Document Type
Academic Journal
Author
Song, Seung Ha; Lee, Hoan Jong; Song, Eun Song; Ahn, Jong Gyun; Park, Su Eun; Lee, Taekjin; Cho, Hye-Kyung; Lee, Jina; Kim, Yae-Jean; Jo, Dae Sun; Kim, Jong-Hyun; Kang, Hyun Mi; Lee, Joon Kee; Kim, Chun Soo; Kim, Dong Hyun; Kim, Hwang Min; Choi, Jae Hong; Eun, Byung Wook; Kim, Nam Hee; Cho, Eun Young; Kim, Yun-Kyung; Oh, Chi Eun; Kim, Kyung-Hyo; Ma, Sang Hyuk; Jung, Hyun Joo; Lee, Kun Song; Kim, Kwang Nam; Lee, Hyunju; Choi, Eun Hwa
Source
The Pediatric Infectious Disease Journal. Dec 01, 2022 41(12):941-946
Subject
Language
English
ISSN
0891-3668
Abstract
OBJECTIVES:: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. METHODS:: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006–2020. Cases were classified as an early-onset disease (EOD) (0–6 days) or late-onset disease (LOD) (7–89 days). The temporal trend change in proportion of pathogens was analyzed. RESULTS:: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = −0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). CONCLUSION:: During 2006–2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.