부산대학교 도서관

OBJECTIVE:: Arterial stiffness (AS) is organ damage influencing the prognosis of patients with cardiovascular (CV) disease. Ambulatory arterial stiffness index (AASI) is a parameter of AS derived from ambulatory blood pressure monitoring (ABPM) which confirmed its predictive value in patients with arterial hypertension.The aim of our prospective study was to investigate the predictive value of AASI in patients after myocardial infarction (MI). DESIGN AND METHOD:: 90 patients after MI was enrolled in the study. At baseline (2 weeks ± 7 days after MI) we performed ABPM. Primary endpoints were CV death, re-MI, unstable angina (UA), the necessity of coronary bypass grafting (CABG), the necessity of cardioverter-defibrillator implantation (ICD) due to heart failure.During 64-month follow up we registered 5 CV death, 2 re-MI, 15 UA, 2 CABG, 2 ICD implantation.(Figure is included in full-text article.) RESULTS:: In an analysis of Kaplan Meier survival curves those who were above the median (cut off 0,4235) (Fig.1), of AASI had a worse prognosis compared to those who were below it (Log Rank 8.347, p = 0.004) for CV event. In multiple Cox regression risk of primary endpoints increased when AASI was > 0.4235 (HR 7.899, 95% CI 1.835–33.994, p = 0.006). CONCLUSIONS:: AASI is a good predictor of CV events in patients after MI and if there is such a possibility should be taken into account in the assessment of prognosis.