부산대학교 도서관

OBJECTIVE:: The goal of the current study was to investigate the perioperative outcomes of robotic pancreaticoduodenectomy (RPD) and open pancreaticoduodenectomy (OPD) in a high-volume center. BACKGROUND:: Despite RPDs prospective advantages over OPD, current evidence comparing the 2 has been limited and has prompted further investigation. The aim of this study was to compare both approaches while including the learning curve phase for RPD. METHODS:: A 1:1 propensity score-matched analysis of a prospective database of RPD with OPD (2017–2022) at a high-volume center was performed. The main outcomes were overall- and pancreas-specific complications. RESULTS:: Of 375 patients who underwent PD (OPD n=276; RPD n=99), 180 were included in propensity score-matched analysis (90 per group). RPD was associated with less blood loss [500 (300–800) vs 750 (400–1000) mL; P=0.006] and more patients without a complication (50% vs 19%; P<0.001). Operative time was longer [453 (408–529) vs 306 (247–362) min; P<0.001]; in patients with ductal adenocarcinoma, fewer lymph nodes were harvested [24 (18–27) vs 33 (27–39); P<0.001] with RPD versus OPD. There were no significant differences for major complications (38% vs 47%; P=0.291), reoperation rate (14% vs 10%; P=0.495), postoperative pancreatic fistula (21% vs 23%; P=0.858), and patients with the textbook outcome (62% vs 55%; P=0.452). CONCLUSIONS:: Including the learning phase, RPD can be safely implemented in high-volume settings and shows potential for improved perioperative outcomes versus OPD. Pancreas-specific morbidity was unaffected by the robotic approach. Randomized trials with specifically trained pancreatic surgeons and expanded indications for the robotic approach are needed.