학술논문
Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis
Document Type
Academic Journal
Author
Sarafidis, Pantelis; Agarwal, Rajiv; Pitt, Bertram; Wanner, Christoph; Filippatos, Gerasimos; Boletis, John; Tuttle, Katherine R.; Ruilope, Luis M.; Rossing, Peter; Toto, Robert; Anker, Stefan D.; Liu, Zhi-Hong; Joseph, Amer; Ahlers, Christiane; Brinker, Meike; Lawatscheck, Robert; Bakris, George; Aizenberg, Diego; Bartolacci, Inés; Besada, Diego; Bittar, Julio; Chahin, Mariano; Elbert, Alicia; Gelersztein, Elizabeth; Liberman, Alberto; Maffei, Laura; Manghi, Federico Pérez; Sanabria, Hugo; Vallejos, Augusto; Viñes, Gloria; Wassermann, Alfredo; Abhayaratna, Walter; Acharya, Shamasunder; Ekinci, Elif; Lee, Darren; MacIsaac, Richard; Mah, Peak Mann; Nelson, Craig; Packham, David; Pape, Alexia; Roger, Simon; Stephenson, Hugo; Suranyi, Michael; Wittert, Gary; Vale, Elizabeth; Colman, Peter; Colquhoun, David; Ellis, Chris; Joshua, Kim; Pedagogos, Eugenia; Regal, Paul; Topliss, Duncan; Vandeleur, James; Verjans, Johan; Wittert, Gary; Wynne, Katie-Jane; Clodi, Martin; Ebenbichler, Christoph; Fliesser-Görzer, Evelyn; Hanusch, Ursula; Krebs, Michael; Lhotta, Karl; Ludvik, Bernhard; Mayer, Gert; Neudorfer, Peter; Paulweber, Bernhard; Prager, Rudolf; Preiß, Wolfgang; Prischl, Friedrich; Schernthaner, Gerit-Holger; Sourij, Harald; Wiesholzer, Martin; Drexel, Heinz; Oberbauer, Rainer; Schönherr, Hans-Robert; Doubel, Peter; Engelen, Wendy; Gillard, Pieter; Hougardy, Jean-Michel; Krzesinski, Jean-Marie; Maes, Bart; Speeckaert, Marijn; Stas, Koen; van Gaal, Luc; Vanbelleghem, Hilde; Duyck, Francis; Scheen, André; Antunes, Daniela; Botelho, Roberto; Brito, Claudia; Canani, Luis; Canziani, Maria Eugenia; Cerqueira, Maria; de Paula, Rogerio; Eliaschewitz, Freddy; Figueiredo, Carlos Eduardo; Forti, Adriana; Hissa, Miguel; Leite, Emerson Lima Maurilo, Jr; Noronha, Irene; Paolino, Bruno; Paschoalin, Nathalia; Paschoalin, Raphael; Filho, Roberto Pecoits; Pereira, Marcio; Portes, Evandro; Precoma, Dalton; Rea, Rosangela; Riella, Miguel; Salles, Joao Eduardo; Vasconcellos, Eduardo; Vencio, Sergio; Bacci, Marcelo; Maia, Lilia; Villacorta, Aline; Apostolova, Emiliya; Boshnyashka, Radostina; Farah, Ghassan; Georgiev, Dimitar; Gushterova, Valentina; Klyuchkova, Neli; Lucheva, Mariya; Manova, Petya; Minkova, Dotska; Nonchev, Boyan; Pichmanova, Mariyana; Prakova, Zhulieta; Rangelov, Rangel; Rashkov, Rosen; Stanchev, Pavel; Stoyanovska-Elencheva, Bilyana; Tagarev, Zhivko; Temelkova-Kurktschieva, Theodora; Vasileva, Svetla; Yoncheva-Mihaylova, Mariana; Marinchev, Angel; Miteva, Mariya; Barre, Paul; Carlson, Brian; Conway, James; Cournoyer, Serge; Dumas, Richard; Fikry, Sameh; Goluch, Richard; Hamet, Pavel; Hart, Randolph; Henein, Sam; Liutkus, Joanne; Madore, Francois; Martinho, Valdemar; Mazza, Giuseppe; McFarlane, Philip; Keefe, Dennis O′; Peterson, Sean; Schwartz, Daniel; Shu, Daniel; Steele, Andrew; Tellier, Guy; Tennankore, Karthik; Tobe, Sheldon; Tsoukas, George; Tytus, Richard; Vitou, Louise; Walsh, Michael; Weisnagel, Stanley; Wilderman, Igor; Yale, Jean-Francois; El Boreky, Fadia; Kelly, Alan; Leiter, Lawrence; Teitelbaum, Ivor; Cobos, Jorge; Godoy, Juan; González, Fernando; Lobos, Sergio; Palma, Juan Carlos; Prieto Dominguez, Juan Carlos; Reyes, Eliana; Romero, Carmen; Saavedra, Victor; Vega, Mario; Medina, Marcelo; Varleta, Paola; Bu, Ruifang; Cai, Hanqing; Chen, Nan; Chen, Qinkai; Chen, Dejun; Cheng, Jinluo; Dong, Youping; Dong, Junwu; Guan, Tianjun; Hao, Chuanming; Huang, Wen; Jiang, Fangfang; Lei, Minxiang; Li, Ling; Li, Zhonghe; Li, Xuemei; Li, Jingmei; Li, Yan; Liang, Xinling; Liang, Bo; Liu, Fang; Liu, Yinghong; Liu, Yuantao; Liu, Zhihong; Long, Gang; Lu, Guoyuan; Lu, Weiping; Lu, Yibing; Luo, Ping; Ma, Jianhua; Mo, Zhaohui; Niu, Jianying; Peng, Ai; Shen, Jiansong; Shen, Feixia; Shi, Bingyin; Su, Qing; Sun, Zhuxing; Tang, Shuifu; Tong, Nanwei; Wang, Hao; Wang, Xinjun; Wang, Guixia; Wang, Jianqin; Wang, Yangang; Wang, Li; Wei, Jiali; Wu, Tianfeng; Wu, Chaoqing; Xing, Changying; Xiong, Fei; Xu, Xudong; Xu, Ning; Yan, Tiekun; Yang, Jinkui; Yin, Aiping; Zeng, Longyi; Zhang, Hao; Zhang, Yanlin; Zhang, Ying; Zhao, Wenjing; Zhao, Zhiquan; Zheng, Hongguang; Zhong, Ling; Zhu, Dalong; Zhuang, Yongze; Du, Yuming; Fang, Yi; Guo, Weiying; Jiang, Sheng; Kuang, Jian; Li, Dongmei; Li, Hongmei; Li, Yinan; Li, Yuxiu; Liu, Jian; Liu, Yu; Miao, Heng; Peng, Wen; Wang, Lihua; Xu, Mingtong; Zhong, Liyong; Zhu, Jun; Arango, Clara; Barrera, Sandra; López, Nelly Beltrán; Benitez, Diego; Blanco, Guillermo; Cadena, Andrés; Coronel, Julian; Cure, Carlos; Durán, Carlos; González, Alexander; Guzmán, Gustavo; Hernández, Eric; Ibarra, Jaime; Jaramillo, Carlos; Jaramillo, Nicolás; Kattah, William; Molina, Dora; Sánchez, Gregorio; Terront, Mónica; Trujillo, Freddy; Urina, Miguel; Vargas, Ruben; Villegas, Iván; Yupanqui, Hernán; Arcos, Edgar; Aroca, Gustavo; Barreto, Germán; Bermudez, Andres; Botero, Rodrigo; Cárdenas, Tatiana; Figueroa, Wilmer; Jaramillo, Mónica; Liévano, Manuel; López, Mónica; Molina, Dora; Rosero, Ricardo; Trillos, Pedro; Dino Alferi; Brada, Michal; Brezina, Jiri; Bucek, Petr; Edelsberger, Tomas; Gulakova, Drahomira; Zapletalova, Jitka Hasalova; Hola, Olga; Hornova, Lucie; Houdova, Jana; Hrmova, Helena; Karasek, David; Kopecka, Sarka; Kovar, Richard; Krcova, Eva; Kuchar, Jiri; Kutejova, Vlasta; Lubanda, Hana; Matyasek, Ivo; Mokrejsova, Magdalena; Okenka, Libor; Prazny, Martin; Pumprla, Jiri; Tomanek, Pavel; Andersen, Ulla; Andries, Alin; Bech, Jesper; Faber, Jens; Gislason, Gunnar; Hangaard, Jørgen; Pacyk, Grzegorz Jaroslaw; Juhl, Claus; Krarup, Thure; Lindhardt, Morten; Madsbad, Sten; Nielsen, Joan; Pedersen-Bjergaard, Ulrik; Poulsen, Per; Rasmussen, Ole; Rossing, Peter; Schousboe, Karoline; Gram, Jeppe; Lauridsen, Thomas; Pedersen, Erling; Thorsteinsson, Birger; Flöjt, Päivi; Honkasalo, Mikko; Honkasalo, Mikko; Humaloja, Kari; Kananen, Kristiina; Kantola, Ilkka; Koistinen, Arvo; Korsoff, Pirkko; Lahtela, Jorma; Nieminen, Sakari; Nieminen, Tuomo; Sadeharju, Karita; Strand, Jorma; Sulosaari, Sakari; Cariou, Bertrand; Chantrel, François; Clavel, Sylvaine; Combe, Christian; Fauvel, Jean-Pierre; Gallouj, Karim; Gouet, Didier; Guerci, Bruno; Guerrot, Dominique; Hourmant, Maryvonne; Klein, Alexandre; Mariat, Christophe; Marre, Michel; Mesbah, Rafik; Le Meur, Yannick; Monier, Arnaud; Moranne, Olivier; Roussel, Ronan; Serusclat, Pierre; Vendrely, Benoit; Verges, Bruno; Zaoui, Philippe; Axthelm, Christoph; Bergmann, Andreas; Birkenfeld, Andreas L.; Braun, Hermann; Busch, Klaus; Contzen, Christel; Degenhardt, Stefan; Derwahl, Karl; Giebel, Thomas; Hagenow, Andreas; Haller, Hermann; Hasslacher, Christoph; Horacek, Thomas; Jungmair, Wolfgang; Kloos, Christof; Koch, Thorsten; Krüger, Thilo; Mühlfeld, Anja; Müller, Joachim; Pfützner, Andreas; Pistrosch, Frank; Rinke, Andrea; Rose, Ludger; Rump, Lars; Schettler, Volker; Schiefke, Ingolf; Schlichthaar, Heike; Schröppel, Bernd; Schöll, Norbert; Schubert, Kristin; Schürholz, Thomas; Sigal, Helena; Stemler, Lutz; Strack, Georg; Täschner, Heidrun; Toursarkissian, Nicole; Tschöpe, Diethelm; Ulmer, Achim; van der Giet, Markus; Wanner, Christoph; Winkelmann, Bernhard R.; Boletis, Ioannis; Dimitriadis, George; Hatziagelaki, Erifili; Iatrou, Christos; Ioannidis, Ioannis; Kounadi, Theodora; Makriniotou, Ioanna; Papadopoulou, Dorothea; Papagianni, Aikaterini; Passadakis, Ploumis; Piaditis, George; Stefanidis, Ioannis; Tai Pang Ip; Lee, Paul; Andrea Luk, On Yan; Ma, Ronald; Chow, Wing Sun; Wang, Angela; Yeung, Vincent; Bajcsi, Dora; Danos, Peter; Harcsa, Eleonora; Kalina, Akos; Kazup, Szilvia; Keltai, Katalin; Kirschner, Robert; Kiss, Julianna; Kovacs, Laszlo; Lamboy, Beata; Literati-Nagy, Botond; Mileder, Margit; Nagy, Laszlo; Noori, Ebrahim; Nyirati, Gabor; Petro, Gizella; Schneider, Karoly; Simon, Judit; Szocs, Albert; Vasas, Szilard; Wudi, Krisztina; Zilahi, Zsolt; Zsom, Marianna; Eustace, Joe; Holian, John; Reddan, Donal; Meara, Yvonne O′; Abramof Ness, Rosane; Adawi, Faiad; Armaly, Zaher; Atar, Shaul; Bashkin, Amir; Ben Chetrit, Sydney; Yanay, Noa Berar; Chernin, Gil; Darawsha, Mahmud; Efrati, Shai; Elias, Mazen; Farber, Evgeny; Glandt, Mariela; Grossman, Ehud; Halabi, Majdi; Harman-Boehm, Ilana; Khazim, Khaled; Liberty, Idit; Minuchin, Oscar; Mosenzon, Ofri; Nakhoul, Farid; Nimer, Assy; Schwartz, Doron; Wainstein, Julio; Yagil, Yoram; Zukermann, Robert; Avogaro, Angelo; Battaglia, Giovanni Giorgio; Bevilacqua, Maurizio Tiziano; Bonora, Enzo; Bossi, Carlo Antonio; Calabrò, Paolo; Cavalot, Franco Luigi; Cimino, Roberto; Cozzolino, Mario Gennaro; David, Salvatore; Emdin, Michele; Fiaccadori, Enrico; Fiorina, Paolo; Giorda, Carlo Bruno; Gregorini, Maria Cristina; La Manna, Gaetano; Maggi, Davide Carlo; Manti, Roberta; Meregalli, Giancarla; Pani, Antonello; Parvanova, Aneliy Ilieva; Perico, Norberto; Piatti, PierMarco; Pisani, Antonio; Pontiroli, Antonio Ettore; Ponzani, Paola; Santorelli, Gennaro; Santoro, Domenico; Scanziani, Renzo; Teatini, Ugo; Tonolo, Giancarlo; Trevisan, Roberto; Veronelli, Anna Maria; Viviani, Giorgio Luciano; Araki, Hideo; Bando, Yukihiro; Ebisui, Osamu; Fujita, Naruhiro; Fukasawa, Hirotaka; Furuya, Ryuichi; Hamamoto, Yoshiyuki; Hamasaki, Akihiro; Hasegawa, Kotaro; Hatazaki, Masahiro; Hayashi, Terumasa; Higashi, Takayuki; Hirohata, Yoshihide; Horinouchi, Shuji; Hoshi, Ayumu; Imoto, Hirofumi; Inagaki, Akemi; Inagaki, Masayuki; Inaguma, Daijo; Inoue, Toshihiko; Ishii, Masao; Ishiko, Tamayo; Isono, Motohide; Jinnouchi, Hideaki; Kanai, Hidetoshi; Kanda, Daisuke; Kanehara, Hideo; Kashima, Masayuki; Kataoka, Yuko; Katayama, Shigehiro; Kato, Kiyoe; Katsuki, Takeshi; Kawamitsu, Katsunori; Kawasaki, Satsuki; Kikuchi, Fumi; Kikuchi, Hidetoshi; Kishimoto, Rui; Kobayashi, Kunihisa; Koide, Junko; Komi, Rieko; Kubota, Miyuki; Kuriya, Genpei; Kurose, Takeshi; Kusano, Yoshiro; Hajime, Maeda; Matsubayashi, Sunao; Matsumoto, Kazunari; Matsumura, Naoya; Matsuo, Yasuto; Matsuoka, Naoki; Miyaoka, Hiroaki; Miyata, Satoshi; Morita, Takeshi; Murakami, Isao; Murao, Satoshi; Nakamura, Udai; Nakayama, Mikihiro; Nakazawa, Jun; Nohara, Sakae; Nomiyama, Takashi; Noritake, Masayuki; Oda, Yoshiaki; Ogiwara, Takayuki; Ohashi, Hiroshi; Okamoto, Hideki; Okino, Shinichi; Osonoi, Takeshi; Sasaki, Nobuhiro; Sayo, Yoshitaka; Sekigami, Taiji; Shibasaki, Taro; Shibata, Hirotaka; Shimoyama, Tatsushi; Shinoda, Junji; Sobajima, Hiroshi; Sugitatsu, Kazuya; Sugiura, Toshiyuki; Sugiyama, Toru; Suzuki, Daisuke; Suzuki, Hiroyuki; Suzuki, Masaaki; Takeda, Asami; Tanaka, Asami; Tanaka, Seiichi; Tsunematsu, Izumi; Ueda, Yasuo; Uekihara, Soichi; Ujihara, Makoto; Yajima, Ken; Yamada, Daishiro; Yamada, Masayo; Yamagata, Kazuo; Yamakawa, Ken; Yamakawa, Fumiko; Yamasaki, Yoshimitsu; Yambe, Yuko; Yanagida, Taihei; Yanai, Hidekatsu; Yanase, Toshihiko; Yasuda, Tetsuyuki; Kriauciuniene, Dovile; Lasiene, Jurate; Navickas, Antanas; Radzeviciene, Lina; Urbanaviciene, Egle; Urbonas, Gediminas; Velaviciene, Audrone; Abd Ghani, Rohana; Aziz, Nor Azizah; Lee, Li Yuan; Loh, Chek Loong; Ali, Norhaliza Mohd; Noor, Nurain Mohd; Fatnoon Nik Ahmad, Nik Nur; Ratnasingam, Jeyakantha; Halimi Bin Wan Hasan, Wan Hasnul; Izani Wan Mohamed, Wan Mohd; Khir, Rizmy Najme; Mohamad, Masni; Alexander Tan, Tong Boon; Avila Pardo, Sandro; Adrian, Miriam Bastidas; Wong, Alfredo Chew; Escobedo de la Peña, Jorge; Salmón, Guillermo Fanghänel; Gálvez, Guillermo González; Ochoa, Ramiro Gutiérrez; Santana, Saúl Irizar; Rovalo, Magdalena Madero; Machado, Gustavo Méndez; Ruiz, Luis Nevarez; Ibarra, Denisse Ramos; López, Gabriel Ramos; Reyna, Leobardo Sauque; Ortiz, Gustavo Solache; Ortiz, Rafael Valdez; Mesa, Juan Villagordoa; Salazar, Melchor Alpizar; Hernández, Pedro García; González, José; Soto, José Lazcano; Mendoza, Arturo Saldaña; Santana, Sergio Irizar; Vilchis, Elvira González; Bakker, R.C.; Barendregt, J.N.M.; Boonstra, A.H.; Bos, Willem; Brouwer, C.B.; Buren, M. van; Gansevoort, Ron; Kooy, Adriaan; Krekels, Marielle; Leendert, Ruud J.M. van; Lieverse, Louis A.G.; Luik, P.T.; Penne, E. Lars; Gregoor, Peter Smak; Vogt, Liffert; Born, Bert-Jan van den; John Baker; Crawford, Veronica; Cutfield, Rick; Dunn, Peter; Krebs, Jeremy; Nirmalaraj, Kingsley; Scott, Russell; Smuts, Nine; Titchener, Janet; Eriksen, Erik; Finnes, Trine; Høivik, Hans; Karlsson, Thomas; Munk, Peter Scott; Radtke, Maria; Risberg, Knut; Rocke, Jan; Solnør, Leidulv; Stenehjem, Aud-Eldrid; Tafjord, Anne-Beathe; Asprusten, Emil; Hagemeier, Robert; Høye, Kjetil; Selsås, Hilde; Thorup, Frode; Wium, Cecilie; Pamugas, Glenda; Panelo, Araceli; Perez, Ronald; Tanque, Maribel; Tirador, Louie; Villa, Michael; Bautista, Albert; Catindig, Elizabeth; Manalo, Carlo; Mirasol, Roberto; Butrymowicz, Patrycja; Ciechanowski, Kazimierz; Cieslik, Grazyna; Franek, Edward; Gumprecht, Janusz; Hoffmann, Michal; Krzykowska, Jolanta; Kurnatowska, Ilona; Landa, Katarzyna; Madrzejewski, Adam; Madziarska, Katarzyna; Mazur, Stanislaw; Napora, Piotr; Nowicki, Michal; Ocicka-Kozakiewicz, Anna; Rewerska, Barbara; Rusicka, Teresa; Ruxer, Jan; Skokowska, Ewa; Stankiewicz, Andrzej; Stompor, Tomasz; Tiuryn-Petrulewicz, Agnieszka; Wasilewska, Katarzyna; Wierusz-Wysocka, Bogna; Wnetrzak-Michalska, Renata; Jedynasty, Krystyna; Anand, Izabela Sein; Almeida, Edgar; Ballesteros, Rosa; Barreto, Carlos; Beirao, Idalina; Birne, Rita; Esteves, Cesar; Guia, Jose; Heitor, Susana; Marques, Olinda; Melo, Pedro; Nolasco, Fernando; Pereira, Amalia; Roque, Cristina; Rosario, Francisco; Silva, Gil; Silva, Ana; Teixeira e Costa, Fernando; Lobos, Ana Vila; Alves, Ana Rita; Brandao, Ilidio; Carvalho, Rui; Coelho, Joao; Lourenco, Ana; Matos, Pedro; Rosario, Vanisa; Neves, Joao Sergio; Cortes-Maisonet, Gregorio; Roman-Miranda, Amaury; Brito-Peguero, Yudit; Colon-Vega, Gildred; Albota, Adrian; Bala, Cornelia; Barbonta, Hortensia; Caceaune, Elena; Catrinoui, Doina; Constantin, Ciprian; Dumitrescu, Adriana; Mindrescu, Nicoleta; Mistode, Cristina; Negrisanu, Gabriela; Onaca, Adriana; Paveliu, Silvia; Pintilei, Ella; Pop, Lavinia; Popa, Amorin; Popescu, Alexandrina; Radulian, Gabriela; Szilagyi, Iosif; Turcu, Liana; Vacaru, Georgeta; Vlad, Adrian; Filimon, Adriana; Veresiu, Ioan; Antsiferov, Mikhail; Arkhipov, Mikhail; Babkin, Andrey; Barbarash, Olga; Baranov, Vitaliy; Chernyavskaya, Elena; Demko, Arkadiy; Dreval, Alexander; Edin, Anton; Ermakova, Polina; Fadeev, Valentin; Galyavich, Albert; Gaysina, Leyla; Gordeev, Ivan; Ipatko, Irina; Kalashnikova, Marina; Khalimov, Yuriy; Klimontov, Vadim; Kobalava, Zhanna; Kosmacheva, Elena; Koziolova, Natalya; Sergey Levashov, Lyudmila Kvitkova; Libis, Roman; Marasaev, Vyacheslav; Malykh, Natalia; Martynenko, Vladimir; Malyutina, Sofya; Merai, Imad; Mkrtumyan, Ashot; Nechaeva, Galina; Petunina, Nina; Palyutin, Shamil; Pimenov, Leonid; Rechkova, Elena; Rodionova, Tatyana; Rymar, Oksana; Sardinov, Ruslan; Semenova, Olga; Sherenkov, Alexander; Solovev, Oleg; Smolyarchuk, Elena; Strongin, Leonid; Ukhanova, Olga; Verlan, Nadezhda; Vorokhobina, Natalya; Yakhontov, Davyd; Yakushin, Sergey; Zakharova, Elena; Zalevskaya, Alsu; Zanozina, Olga; Zhdanova, Elena; Zhukova, Larisa; Zykova, Tatyana; Argunova, Yulia; Nikolaev, Konstantin; Villevalde, Svetlana; Fang Sum, Chee; Suhail, Sufi Muhummad; San Tan, Ru; Vathsala, Anantharaman; Wong, Edmund; Bee, Yong Mong; Babikova, Jana; Buganova, Ingrid; Dzupina, Andrej; Ochodnicka, Zuzana; Sosovec, Dalibor; Spodniakova, Denisa; Minarik, Peter; Fayzal Ahmed; Amod, Aslam; Bhana, Sindeep; Distiller, Larry; Jansen van Rensburg, Dirkie; Joshi, Mukesh; Joshi, Shaifali; Lakha, Deepak; Mitha, Essack; Podgorski, Gracjan; Ranjith, Naresh; Rayner, Brian; Rheeder, Paul; Sarvan, Mohamed; Seeber, Mary; Siebert, Heidi; Tayob, Mohammed; Trokis, Julien; Urbach, Dorothea; van Zyl, Louis; Jansen van Rensburg, Dirkie; Bum-Soon Choi; Choi, Moon Gi; Chung, ChoonHee; Hwang, YouCheol; Kim, ChongHwa; Kim, InJoo; Kim, JaeHyeon; Kim, SinGon; Kim, SungGyun; Kim, Tae Hee; Lee, WooJe; Lee, ByungWan; Lee, Kang Wook; Oh, Kook-Hwan; Oh, Ji Eun; Oh, Yun Kyu; Oh, Dong-Jin; Park, Junbeom; Shin, Seok Joon; Sung, Su-Ah; Yu, Jae Myung; Chung, HyeSoo; Huh, Ji Hye; Kang, JunGoo; Kim, ChulSik; Kim, HyeSoon; Kim, NamHoon; Lim, Soo; Cho, Young Min; Park, Cheol Young; Agraz, Irene; Ampudia, Francisco Javier; Bouarich, Hanane; Calero, Francesca; Castro, Cristina; Guldris, Secundino Cigarrán; Garrit, Josep Cruzado; de Álvaro, Fernando; Galcerán, Josep; Albarrán, Olga González; Jaras, Julio Hernández; Ibernón, Meritxell; Deben, Francisco Martínez; Ma; Esteban, Dolores Martínez; Pascual Izuel, José María; Martins, Judith; Mediavilla, Juan; Michán, Alfredo; Santos, Julio Pascual; Poch, Esteban; Rusillo, Manuel Polaina; Juan, Carlos Sánchez; Olmo, Rafael Santamaría; Segura de la Morena, José Julián; Soto, Alfonso; Troya, Maribel; Castro, Fernando Cereto; Fernández, Pablo Gómez; Sánchez, Laura Fuentes; Moya, Mercedes González; Marrero, Domingo Hernández; Maroto, Gonzalo Piedrola; Redón, Josep; Seron, Daniel; Bruchfeld, Annette; Curiac, Dan; Eliasson, Ken; Frank, Malin; Guron, Gregor; Hellberg, Olof; Hellgren, Margareta; Larnefeldt, Hans; Lindholm, Carl-Johan; Löndahl, Magnus; Rein-Hedin, Erik; Soveri, Inga; Spaak, Jonas; Tengmark, Bengt-Olov; Lif-Tiberg, Cornelia; Månflod, Johan; Nguyen, Han; Ackermann, Daniel; Bilz, Stefan; Burnier, Michel; Forster, Christian; Kalbermatter, Stefan; Kistler, Andreas; Pechère-Bertschi, Antoinette; Schultes, Bernd; Laimer, Markus; Rudofsky, Gottfried; Strey, Christopher; Wuerzner, Gregoire; Chiz-Tzung Chang; Hung, Cheng-Chieh; Jiang, Ju-Ying; Lee, Chien-Te; Lin, Shuei-Liong; Tarng, Der-Cherng; Tu, Shih-Te; Wu, Mai-Szu; Wu, Ming-Ju; Chuang, Lee-Ming; Deerochanawong, Chaicharn; Kitiyakara, Chagriya; Ophascharoensuk, Vuddhidej; Pongchaiyakul, Chatlert; Satirapoj, Bancha; Kosachunhanan, Natapong; Sritara, Piyamitr; Eren, Necmi; Gul, Ibrahim; Gulel, Okan; Kocyigit, Ismail; Kumbasar, Abdulbaki; Sahin, Idris; Sari, Ramazan; Sayin, Burak; Tavli, Talat; Ustundag, Sedat; Yenicerioglu, Yavuz; Badak, Ozer; Cayli, Murat; Oguz, Aytekin; Ozdogan, Oner; Sari, Ibrahim; Temizhan, Ahmet; Tigen, Mustafa; Turk, Ugur; Yilmaz, Huseyin; Yilmaz, Mehmet; Bondarets, Iryna; Botsyurko, Volodymyr; Chernikova, Viktoriia; Donets, Oleksandra; Fushtey, Ivan; Grachova, Mariia; Isayeva, Anna; Kogut, Dmytro; Komisarenko, Julia; Kravchun, Nonna; Malyar, Kateryna; Mankovsky, Borys; Martynyuk, Liliya; Maslyanko, Vitaliy; Myshanych, Halyna; Pererva, Larysa; Pertseva, Nataliia; Serhiyenko, Oleksandr; Smirnov, Ivan; Sokolova, Liubov; Stryzhak, Vasyl; Vlasenko, Maryna; Isayeva, Ganna; Larin, Oleksandr; Ahmad AbouSaleh; Barratt, Jonathan; Dang, Cuong; Kahal, Hassan; Kirk, Adam; Kilvert, Anne; Kon, Sui Phi; McCafferty, Kieran; Patel, Dipesh; Rice, Sam; Vijayaraman, Arutchelvam; Wong, Yuk-ki; Gibson, Martin; Wahba, Mona; Zaidi, Reza; Bilous, Rudy; Johnson, Andrew; Kalathil, Dhanya; Kilvert, Anne; Kyriakidou, Christina; Mathew, Amit; Mukhtar, Rasha; Munsoor, Imrozia; Poterajlo, Anton; Swift, Pauline; Idalia Acosta; Adams, Atoya; Adler, Sharon; Ajani, Dilawar; Ali, Slamat; Alicic, Radica; Al-Karadsheh, Amer; Alla, Sreedhara; Allison, D.; Andrawis, Nabil; Arif, Ahmed; Awad, Ahmed; Azizad, Masoud; Bahrami, Michael; Bansal, Shweta; Barag, Steven; Barakzoy, Ahmad; Barney, Mark; Barzilay, Joshua; Bashir, Khalid; Bautista, Jose; Beddhu, Srinivasan; Belo, Diogo; Benjamin, Sabrina; Berenji, Ramin; Bhargava, Anuj; Birriel, Jose; Brietzke, Stephen; Brosius, Frank; Brusco, Osvaldo; Burgner, Anna; Busch, Robert; Canadas, Rafael; Caramori, Maria; Cardona, Jose; Case, Christopher; Cruz, Humberto; Dandillaya, Ramprasad; Dawoud, Dalia; Din, Zia; Dixon, Bradley; Doshi, Ankur; Drakakis, James; El Shahawy, Mahfouz; El-Meanawy, Ashraf; El-Shahawy, Mohammed; Evans, John; Fadda, George; Farooq, Umar; Fernando, Roland; Fink, Raymond; First, Brian; Fitz-Patrick, David; Flack, John; Fluck, Patrick; Fogelfeld, Leon; Fonseca, Vivian; Frias, Juan; Galphin, Claude; Garcia-Mayol, Luis; Goldstein, Gary; Gonzalez, Edgar; Gonzalez-Abreu, Francisco; Gore, Ashwini; Grant, David; Habwe, Violet; Hamilton, Maxine; Hammoud, Jamal; Handelsman, Stuart; Hartman, Israel; Heigerick, Glenn; Henry, Andrew; Hernandez, German; Hernandez-Cassis, Carlos; Herrera, Carlos; Hertel, Joachim; Huang, Wenyu; Iglesias, Rogelio; Iranmanesh, Ali; Jackson, Timothy; Jain, Mahendra; Jamerson, Kenneth; Johnson, Karen; Judd, Eric; Kaplan, Joshua; Kayali, Zeid; Khan, Bobby; Khan, Muhammad; Kharait, Sourabh; Kirkman, M. Sue; Kopyt, Nelson; Kotzker, Wayne; Kovesdy, Csaba; Kreit, Camil; Krishna, Arvind; Kronfli, Saeed; Lee, Keung; LeJeune, Derek; Lemus, Brenda; Leon-Forero, Carlos; Linfert, Douglas; Lora, Henry; Lurie, Alexander; Maddukuri, Geetha; Magno, Alexander; Maletz, Louis; Mandayam, Sreedhar; Markell, Mariana; Mayfield, Ronald; Mbogua, Caroline; McMullen, Dierdre; Meisner, Carl; Minton, Stephen; Mocherla, Bharat; Mohandas, Rajesh; Montero, Manuel; Moustafa, Moustafa; Nadkarni, Salil; Nakhle, Samer; Navarro, Jesus; Neyra, Nilda; Nica, Romanita; Nicol, Philip; Norwood, Paul; Numrungroad, Visal; Donovan, Richard O′; Odugbesan, A.; Paoli-Bruno, Jorge; Parikh, Samir; Patel, Rakesh; Peixoto, Aldo; Pergola, Pablo; Perlman, Alan; Pettis, Karlton; Pisoni, Roberto; Ponduchi, Mirela; Posada, Jorge; Prabhakar, Sharma; Radhakrishnan, Jai; Rahman, Mahboob; Raina, Rupesh; Rastogi, Anjay; Reisin, Efrain; Rendell, Marc; Robertson, David; Rocco, Michael; Romeu, Hugo; Rosas, Sylvia; Rosenfeld, Jack; Ross, Dennis; Rothman, Jeffrey; Rudolph, Lance; Ruhullah, Yusuf; Ruoff, Gary; Ryu, Jeffrey; Sahani, Mandeep; Sam, Ramin; Samuels, Garfield; Sanchez, William; Santos, Vladimir; Satko, Scott; Saxena, Sanjeev; Scott, David; Seco, Gilberto; Seek, Melvin; Serota, Harvey; Shafi, Tariq; Shahid, Nauman; Shanik, Michael; Sharma, Santosh; Sinha, Arjun; Smelser, James; Smith, Mark; Soe, Kyaw; Solomon, Richard; Soroka, Eugene; Soufer, Joseph; Spinowitz, Bruce; Spry, Leslie; Suarez, Rosa; Subramanian, Bala; Szerlip, Harold; Tamirisa, Aparna; Thomson, Stephen; Tran, Tuan-Huy; Treger, Richard; Trullenque, Gretel; Turk, Thomas; Umpierrez, Guillermo; Urbach, Daniel; Valdes, Martin; Valika, Shujauddin; Vega, Damaris; Weissman, Peter; Whaley-Connell, Adam; Winston, Jonathan; Wise, Jonathan; Wynne, Alan; Zeig, Steven; Abdel-Rahman, Emaad; Abreu, Edel; Awad, Alaa; Bahri, Nader; Bertsch, John; Bleich, David; Bornfreund, Jonathan; Brar, Harjeet; Brian, Susan; Brinson, Cynthia; Bruschetta, Humberto; Carpio, Jose; Cohen, Steven; Cosby, John; Dhanireddy, Soni; Diaz, Jorge; Dunn, Fredrick; Eppanapally, Sabitha; Fayad, Joseph; Goel, Archana; Govindaraju, Kanakadurga; Halpern, Stephen; Jones, Audrey; Kaye, William; Knight, Herbert; Koch, Stanley; Kohli, Nandini; Lastra, Guido; Lerman, Sam; Loredo, Jorge; Lovre, Dragana; Mandviwala, Mustafa; Martin, Earl; Meyer, Jill; Murray, John; Oliver, David; Oparil, Suzanne; Penabad, Jesus; Pereira, Isabel; Popeil, Larry; Quesada, Gonzalo; Ramanathan, Kodangudi; Ramos-Gonez, Luis; Rastegar, Mandana; Rastogi, Padmashri; Rondon, Juan; Roy-Chaudhury, Prabir; Smith, David; Williamson, Don; Womack, Catherine; Yamout, Hala; Yuryev, Michael; Chu, Phuong; Van Hoang, Lam; Khanh, Tran; Phi Nga, Nguyen Thi; Son, Pham Nguyen; Tran, Lan Phuong; Le, Thuy Khuong; Nguyen, Boi Ngoc; Nguyen, Thao; Nui, Nguyen Minh; Nam, Tran Quang; Tran, Kim Chi
Source
Clinical Journal of the American Society of Nephrology. May 01, 2023 18(5):602-612
Subject
Language
English
ISSN
1555-9041
Abstract
BACKGROUND: Patients with stage 4 CKD and type 2 diabetes have limited treatment options to reduce their persistent cardiovascular and kidney risk. In Finerenone in Chronic Kidney Disease and Type 2 Diabetes (FIDELITY), a prespecified pooled analysis of Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease (FIDELIO-DKD) and Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD), finerenone improved heart-kidney outcomes in participants with CKD and type 2 diabetes. METHODS: This FIDELITY subgroup analysis investigated the effects of finerenone in participants with stage 4 CKD (eGFR <30 ml/min per 1.73 m). Efficacy outcomes included a cardiovascular composite (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) and a kidney composite (kidney failure, sustained ≥57% decrease in eGFR from baseline, or kidney disease death). RESULTS: Of 13,023 participants, 890 (7%) had stage 4 CKD. The hazard ratio for risk of cardiovascular composite outcome with finerenone versus placebo was 0.78 (95% confidence interval, 0.57 to 1.07). The kidney composite outcome proportional hazards assumption was not met for the overall study period, with a protective effect only shown up to 2 years, after which the direction of association was inconsistent, and an observed loss of precision over time incurred on finerenone versus placebo risk differences. Nonetheless, albuminuria and rate of eGFR decline were consistently reduced with finerenone versus placebo. Adverse events were balanced between treatment arms. Hyperkalemia was the most common adverse event reported (stage 4 CKD: 26% and 13% for finerenone versus placebo, respectively); however, the incidence of hyperkalemia leading to permanent discontinuation was low (stage 4 CKD: 3% and 2% for finerenone versus placebo, respectively). CONCLUSIONS: The cardiovascular benefits and safety profile of finerenone in participants with stage 4 CKD were consistent with the overall FIDELITY population; this was also the case for albuminuria and the rate of eGFR decline. The effects on the composite kidney outcome were not consistent over time.