부산대학교 도서관

OBJECTIVES:: To determine the incidence of bleeding in critically ill children with malignancy and to describe associated patient characteristics, interventions, and clinical outcomes. DESIGN:: Prospective cohort study. SETTING:: PICU in a specialized cancer hospital. PATIENTS:: Children with malignancy or hematopoietic cell transplant 0–18 years of age were admitted to the PICU from November 2020 to November 2021. INTERVENTIONS:: None. MEASUREMENTS:: Patient demographic data, laboratory values, and PICU outcome data were collected. Bleeding was classified according to the Bleeding Assessment Scale in Critically Ill Children. MAIN RESULTS:: Ninety-three bleeding patients were enrolled, and a total of 322 bleeding days were recorded. The median (interquartile range [IQR]) age was 5.8 (2.9–11.8) years and 56% (52/93) of the patients were male. There were 121 new bleeding episodes, in 593 at-risk person-days, translating into a 20% incidence rate per day (95% CI, 17–24%). The incidence of severe, moderate, and minimal bleeding was 2% (95% CI, 1–3), 4% (95% CI, 3–6), and 14% (95% CI, 12–17), respectively. Of the new bleeding episodes, 9% were severe, 25% were moderate and 66% were minimal. Thrombocytopenia was the only laboratory value independently associated with severe bleeding (p = 0.009), as compared to minimal and moderate bleeding episodes. History of radiation therapy was independently associated with severe bleeding (p = 0.04). We failed to identify an association between a history of stem cell transplant (p = 0.49) or tumor type (p = 0.76), and bleeding severity. Patients were transfused any blood product on 28% (95% CI, 22–34) of the bleeding days. Severe bleeding was associated with increased length of mechanical ventilation (p = 0.003), longer PICU stays (p = 0.03), and higher PICU mortality (p = 0.004). CONCLUSIONS:: In this prospective cohort of children with malignancy, the incidence rate of bleeding was 20%. Most events were classified as minimal bleeding. Low platelet count and radiation therapy were variables independently associated with severe bleeding episodes.