부산대학교 도서관

OBJECTIVE:: In post-Soviet countries, mortality rates from CVD are one of the highest in the world. High hypertension prevalence and low control is the common problem for most CIS countries.Aim is to study the association of hypertension with cardiovascular morbidity and mortality among rural residents of the two countries: Russia, the Kyrgyz Republic, with an analysis of ethnic characteristics (according to the Interepid study) DESIGN AND METHOD:: This study was carried out as part of the international project Interepid, which included a one-stage epidemiological study of the prevalence of major chronic noncommunicable diseases and their risk factors, and a prospective stage among residents of small towns and rural areas of the two countries. The analysis includes the results of a survey of representative samples of the rural population of the Samara Region of Russian Federation (n = 1050), the Chui region of the Kyrgyz Republic (n = 1341) aged 20–64. The study in Russia and the Kyrgyz Republic was conducted according to a same protocol. The following endpoints are included in the analysis: 1. Cases of death from all causes 2. Deaths from CVD 3. Cases of non-fatal cardiovascular events (non-fatal myocardial infarction(MI), nonfatal stroke), unstable angina pectoris, revascularization (surgery-aortocoronary bypass, percutaneous angioplasty, carotid endarterectomy, revascularization of the arteries of the lower extremities) RESULTS:: Prospective follow-up was 3.9 years. Hypertension impact was insignificant on the outcomes in the Samara region, but not in Kyrgyz Republic. In Kyrgyz Republic among Russian population hypertension was significantly associated with all-cause mortality (RR 2.27(95% CI 1.09; 3.61), p < 0.01), cardiovascular mortality (RR 2.98 (95% CI 1.14; 5.37), p < 0.01), non-fatal endpoints (RR 3.30 (95% CI 1.30; 6.06), p < 0.01). Among native population hypertension was associated only with non-fatal endpoints (RR 1.47 (95% CI 1.12; 1.88), p < 0.05) CONCLUSIONS:: Despite a short observation period, the results indicate significant unfavourable effect of hypertension on the risk of cardiovascular morbidity, with ethnic and country differences. All this underlines the need to develop differentiated preventive and treatment and preventive programs adjusted to country specific and ethnic specific differences in hypertension prevalence and its impact on the prognosis