학술논문
Phosphorylated EGFR at tyrosine 1173 correlates with poor prognosis in oral squamous cell carcinomas
Document Type
Academic Journal
Author
Source
Oral Diseases. Mar 01, 2014 20(2):178-185
Subject
Language
English
ISSN
1354-523X
Abstract
OBJECTIVES:: MATERIALS AND METHODS:: RESULTS:: Epidermal growth factor receptor expression was observed in all cases, and pEGFR expression was observed in 41.1% of the cases. We found a significant correlation between EGFR and pEGFR expression (P = 0.003). In the multivariable analysis for cause-specific survival, we found an independent prognostic value for pEGFR expression (HR 7.94, 95% CI 2.03–31.06, P = 0.003) and for clinical stage (HR 2.88, 95% CI 1.10–7.53, P = 0.031). For recurrence-free survival, clinical stage (HR 6.59, 95% CI 1.36–31.90, P = 0.019) and tumour grade (HR 3.35, 95% CI 1.07–10.44, P = 0.037) presented independent prognostic value. CONCLUSION