학술논문
Identification of Cxcl13 As A Marker For Rheumatoid Arthritis Outcome Using An in Silico Model of the Rheumatic Joint
Document Type
Academic Journal
Author
Source
Arthritis & Rheumatism. May 01, 2011 63(5):1265-1273
Subject
Language
English
ISSN
0004-3591
Abstract
OBJECTIVE.: METHODS.: RESULTS.: Comparison of high and low quartiles of erosion score and SHS at 4 years showed a difference in baseline serum CXCL13 level (P = 0.011 and P = 0.018, respectively). In the confirmation cohort, elevated baseline CXCL13 levels were associated with increased rates of joint destruction during 7 years of followup (P < 0.001 unadjusted and P ≤ 0.004 with adjustment for C-reactive protein level). Analyzing anti–CCP- 2–positive and anti–CCP-2–negative RA separately yielded a significant result only in the anti–CCP- 2–negative group (P ≤ 0.001). CONCLUSION.