부산대학교 도서관

BACKGROUND:: There has been no consensus regarding whether lead poisoning can cause osteoporosis and whether estradiol exhibits curative effects on osteoporosis. OBJECTIVE:: To observe the curative effects of estradiol on osteoporosis-induced by ovariectomy and lead poisoning in rats. METHODS:: A total of 100 female rats were randomly and evenly divided into five groups: normal control, ovariectomized, lead poisoning, estradiol+ovariectomized and estradiol+lead poisoning. At 1 week after ovariectomy, estradiol (100 μg/kg) was subcutaneously injected into the rats in the estradiol+ovariectomized and estradiol+lead poisoning groups, twice a week, for successive 12 weeks. RESULTS AND CONCLUSION:: In the ovariectomized group and lead poisoning group, calcium and phosphorus levels in the bone and serum were significantly decreased (P < 0.01), serum level of alkaline phosphatase was significantly increased (P < 0.01), and bone tissue showed the pathological change of osteoporosis. In the estradiol+ovariectomized group, serum levels of calcium, phosphorus, and alkaline phosphatase and bone tissue morphology returned to normal, while in the estradiol+lead poisoning group, no obvious changes in bone metabolism indices and bone tissue morphology above-mentioned did not recover obviously. The lead level in the bone and serum was significantly higher in the lead poisoning group, estradiol+lead poisoning group than in the normal control group (P < 0.01). These results showed that lead poisoning can cause osteoporosis, and estradiol exhibits good curative effects on osteoporosis-caused by ovariectomy in rats, but it does not produce obvious curative effects on osteoporosis-caused by lead poisoning.Chen BP, Li H, Chen JH, Li B, Zhang SQ. Estradiol does not affect bone tissue and bone metabolism indices in rat models of lead poisoning.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(33): 6131-6134. [http://www.crter.cn http://en.zglckf.com]