부산대학교 도서관

PROBLEM: Listeria monocytogenes (LM) preferentially colonizes the placenta and causes fetal loss and systemic disease during pregnancy. As systemic CD8 T-cell memory is critical in controlling LM infection, we addressed the issue as to whether it is modulated during pregnancy. METHOD OF STUDY: Pregnant mice were infected with LM and their immune response was quantified relative to the non-pregnant cohort using advanced immunological techniques. RESULTS: Pregnant mice exhibited progressive and massive placental LM infection leading to fetal resorptions. In contrast, they harbored significantly lower bacteria in spleen and liver relative to non-pregnant controls, and rapidly cleared systemic infection. Both pregnant and non-pregnant mice exhibited similar activation of systemic innate immunity. Moreover, LM infection in pregnant and non-pregnant hosts evoked strong antigen-specific cytolytic CD8 T cells that produced IFN-γ. Consequently, LM infection initiated during pregnancy afforded long-term protective memory to secondary infection. CONCLUSION: Maternal hosts generate a normal Listeria-specific adaptive immunity in particular CD8 T-cell memory response suggesting that systemic listeriosis during pregnancy may be an immunopathology associated with placental infection.