학술논문
A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA
Document Type
Academic Journal
Author
Schuberth-Wagner, Christine; Ludwig, Janos; Bruder, Ann Kristin; Herzner, Anna-Maria; Zillinger, Thomas; Goldeck, Marion; Schmidt, Tobias; Schmid-Burgk, Jonathan L.; Kerber, Romy; Wolter, Steven; Stümpel, Jan-Philip; Roth, Andreas; Bartok, Eva; Drosten, Christian; Coch, Christoph; Hornung, Veit; Barchet, Winfried; Kümmerer, Beate M.; Hartmann, Gunther; Schlee, Martin
Source
Immunity. Jul 21, 2015 43(1):41-51
Subject
Language
English
ISSN
1074-7613
Abstract
SUMMARY: GRAPHICAL ABSTRACT: (Figure is included in full-text article.) HIGHLIGHTS: : The cytosolic receptor RIG-I initiates immune responses against most RNA viruses by detecting viral RNA. Schlee and colleagues report that a conserved amino acid in the RNA binding pocket prevents recognition of endogenous RNA bearing a N1-2′O-methyl group as a marker of “self” and that flaviviruses exploit this tolerance mechanism for immunoescape.