학술논문
Unbalanced protein S deficiency due to warfarin treatment as a possible cause for thrombosis
Document Type
Academic Journal
Source
British Journal of Haematology. Oct 01, 2007 139(2):310-311
Subject
Language
English
ISSN
0007-1048
Abstract
The prothrombin time/International Normalized Ratio is an accurate parameter for following most warfarin-treated patients. However, it reflects mostly factor VII levels, and significant disproportionate alterations in other vitamin K-dependent factors may not be reflected properly. We report a rare case of a woman who developed arterial thrombosis whilst receiving therapeutic doses of warfarin, and was found to have a significant and unbalanced protein S deficiency. Discontinuation of warfarin resulted in complete normalization of coagulation factors, and no further thrombotic events under treatment with enoxaparin, with a follow-up of 2.5 years.