학술논문
Insulin-like growth factors I and II in the aseptic loosening of total hip implants
Document Type
Academic Journal
Source
Scandinavian Journal of Rheumatology. Nov 01, 2004 33(6):428-431
Subject
Language
English
ISSN
0300-9742
Abstract
Periprosthetic interface tissue and pseudocapsule samples surrounding aseptically loosened hip implants and control knee synovium were studied by reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Endothelial cells, fibroblasts, and monocyte/macrophages contained bone formation-enhancing insulin-like growth factors (IGFs). In interface tissue we found fewer IGF-I and IGF-II positive cells than in control tissue. In pseudocapsular tissue we found fewer IGF-I positive cells and an equal amount of IGF-II positive cells compared to control tissues. Decreased bone formation may contribute to net loss of bone around aseptically loosened hip implants.