학술논문
C-Reactive Protein as a Prognostic Marker After Lacunar Stroke: Levels of Inflammatory Markers in the Treatment of Stroke Study
Document Type
Academic Journal
Author
Elkind, Mitchell S.V.; Luna, Jorge M.; McClure, Leslie A.; Zhang, Yu; Coffey, Christopher S.; Roldan, Ana; Del Brutto, Oscar H.; Pretell, Edwin Javier; Pettigrew, L. Creed; Meyer, Brett C.; Tapia, Jorge; White, Carole; Benavente, Oscar R.; Pettigrew, Creed; Vaishnav, Anand; Sawaya, Peter; Fowler, Anna; Hughes, Nedda; Rice, Johnya; Vanderpool, Kathy; Meyer, Brett; Jackson, Christy; Gamble, Paul; Kelly, Nancy; Warner, Janet; Bell, Jo; Meissner, Irene; Graves, John; Herzig, Deb; Covalt, Jody; Cruz-Flores, Salvador; Walden, H. Douglas; Holzemer, Eve; Coull, Bruce; Howard, Lien; Malekniazi, Mina; VanSkiver, Melissa; Bruck, Denise; Redman, Stacey; Hanna, Joseph; Zipp, Thomas; Bailey, Scott; Cook, Dana; Liskay, Alice; Simcox, Dana; Kappler, Joan; Demaerschalk, Bart; Hogan, Michael; Wochos, Daniel; Wieser, Judith; Cleary, Barbara; Wood, Lori; Katramados, Angelo; Silver, Brian; Yee, Jerry; Aiello, Krisy; Wilson, Kathleen; McCarthy, Sharon; Kase, Carlos; Gavras, Irene; Lau, Helena; Ogrodnik, Matt; Allen, Nancy; Anderson, David; Grimm, Richard; Brauer, Donna; Naritoku, Dean; Zweifler, Richard; Culpepper, Michael; Parnell, Mel; Yunker, Robin; Boots, Kelly; Drinkard, Renay; Backlin, Rachel; Elkind, Mitch; Crew, Russell John; Radhakrishan, Jai; Corporan, Tania E.; Diaz, Julisa; Aragon, Rebeca; Benavente, Oscar; Hart, Robert; Pergola, Pablo; Palacio, Santiago; Castro, Irma; Farias, Arlene; Roldan, Ana; Mirsen, Tom; McAllister, Susan; Bastien, Arnaud; Niblack, Patricia; Sundararajan, Sophia; Rahman, Mahboob; Horvath, Tom; Korosec, David; Murphy, Chris; Lutsep, Helmi; Girard, Don; Seisler, Kali; Cingel, Megan; Ross, Megan; Stone, Rachel; Larsen, Darren; Doherty, Ann; Book, Diane; Eapen, Sunu; Grimm, Clarence; Blaney, Barbara; Rozman, Stephanie; Gaertner, Linda; Bradenburg, Erin; Loomis, Laura; Monarch-Cotton, Jolene; Ravavelli-Meyer, Jean; Golembieski, Anna; Romano, José; Ortiz, Gustavo; del Carmen Lichtenberger, Maria; Johnson, Mark; Liu, Yinghui; Goldsteen, Robert; Blair, April; Wright, Gregg; Gathua, Naomie; Jacoby, Michael; Jones, David; DeFrancisco, Jeffrey; Hamm, Theresa; Burgin, Scott W.; Hollander, Joshua; Polashenski, Walter; Wallace, Patricia; Weber, Cheryl; Greenberg, Jason; Lennihan, Laura; King, Marjorie; Tenteromano, Laura; Pereira, Lorainne; Ching, Marilou; Sawyer, Robert; Parkes, Kathy; Conover, Cheryl; Weinberger, Jesse; Wright, Lewis; Burch, Dorothy; Benesch, Curtis; Bisognano, John; Leonhardt, Ann; Zentner, Justine; Hildreth, Molly; Karanjia, Percy; Murali, Narayana; Dart, Richard; Mancl, Kathleen; Lefkowitz, David; Pavel, Levy; Buchheimer, Nancy; Vaughn, Sara; Smith, Emily; Satterfield, Jean; Van Stavern, Renee; Brown, Angela; Serna, Jannie; Newgent, Jill; Naylor, Julie; Carpenter, Laura; Shuab, Ashfaq; Khan, Khurshid; Dean, Naeen; Herbert, Frederika; Kastelic, Karen; Atkinson, Richard; Lieberman, Roger; Carter, Teresa; Zrelak, Pat; Kenney, Nola; Logan, William; Carpenter, David; Schroer, Sally; Berger, Leo; Brunet, Sylvain; Pontbriand, Johanne; Mainville, Martine; Racicot, Denise; Côté, Robert; Green, Laurence; Wadup, Lisa; Fontaine, Anne-Marie; Tapia, Jorge; Godoy, Ivan Esteban; Valdes, Marcela; Matamala, Gonzalo; Goecke, Helmut; Parra, Marcela; Pozo, Jessica; del Brutto, Oscar; Santibáñez, Rocio; Lara, Joffre; Zambrano, Mauricio; Ruiz Sandoval, José Luis; Vásquez, Eduardo Salcido; Ruiz, Carmen; Arauz, Antonio; Cervantes, G. Amin; Leyva, Adolfo; Camacho, Itzel; Pretell, Edwin Javier; Valdivia, José; Pretell, Marissa; Leal, Joaquín Serena; Castellanos, Mar; Cruz, Verónica; Cepeda, Mercè; Arboix, Adrià; Pelegrí, Antoni; Blanco, Lorena; Borrego, Francisco Rubio; Gudiol, Francisco; Gomis, Meritxell; Arenillas, Juan; Dávalos, Antonio; Suñol, Ana; Reverté, Silvia; Roquer, Jaume; Serrano, Ana Oliveras; Conde, Jordi Jiménez; Rodríguez, Ana; Romeral, Gemma; Sánchez, José Castillo; González, Miguel Blanco; Rodríguez, Manuel; Jiménez, Isabel; Rodríguez, Jaime; McClure, Leslie; Coffey, Christopher; Szychowski, Jeff; Howard, George; Katholi, Charles; Zhang, Yu; Peri, Kalyani; Allcorn, Charles; Mailhot, Richard; Irby, Lisa; Guyton, Fekisha; Sewell, Mary Jo; Benavente, Oscar; Hart, Robert; Pergola, Pablo; Roldan, Ana; Benavente, Marie-France; White, Carole; Robu, Camilla; Kelly, Che; Talbert, Robert; Martinez, Eduardo; Bazan, Carlos; Pergola, Gabriela; Pearce, Lesly; Costello, Raymond; Jacova, Claudia; Camelia, Luisa; Mendoza, Crystal; Pratt, Brandy; Holliday, Steve; Elkind, Mitchell S.V.; Luna, Jorge
Source
Stroke. Mar 01, 2014 45(3):707-716
Subject
Language
English
ISSN
0039-2499
Abstract
BACKGROUND AND PURPOSE—: Inflammatory biomarkers predict incident and recurrent cardiac events, but their relationship to stroke prognosis is uncertain. We hypothesized that high-sensitivity C-reactive protein (hsCRP) predicts recurrent ischemic stroke after recent lacunar stroke. METHODS—: Levels of Inflammatory Markers in the Treatment of Stroke (LIMITS) was an international, multicenter, prospective ancillary biomarker study nested within Secondary Prevention of Small Subcortical Strokes (SPS3), a phase III trial in patients with recent lacunar stroke. Patients were assigned in factorial design to aspirin versus aspirin plus clopidogrel, and higher versus lower blood pressure targets. Patients had blood samples collected at enrollment and hsCRP measured using nephelometry at a central laboratory. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for recurrence risks before and after adjusting for demographics, comorbidities, and statin use. RESULTS—: Among 1244 patients with lacunar stroke (mean age, 63.3±10.8 years), median hsCRP was 2.16 mg/L. There were 83 recurrent ischemic strokes (including 45 lacunes) and 115 major vascular events (stroke, myocardial infarction, and vascular death). Compared with the bottom quartile, those in the top quartile (hsCRP >4.86 mg/L) were at increased risk of recurrent ischemic stroke (unadjusted HR, 2.54; 95% CI, 1.30–4.96), even after adjusting for demographics and risk factors (adjusted HR, 2.32; 95% CI, 1.15–4.68). hsCRP predicted increased risk of major vascular events (top quartile adjusted HR, 2.04; 95% CI, 1.14–3.67). There was no interaction with randomized antiplatelet treatment. CONCLUSIONS—: Among recent lacunar stroke patients, hsCRP levels predict the risk of recurrent strokes and other vascular events. hsCRP did not predict the response to dual antiplatelets. CLINICAL TRIAL REGISTRATION—: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059306.