학술논문
Blood urea nitrogen and serum bicarbonate in extremely low birth weight infants receiving higher protein intake in the first week after birth
Document Type
Academic Journal
Author
Source
Journal of Perinatology. Aug 01, 2011 31(8):535-539
Subject
Language
English
ISSN
0743-8346
Abstract
OBJECTIVE:: To determine correlation between early protein administration and serum blood urea nitrogen (BUN) or bicarbonate (HCO3) in extremely low birth weight (ELBW) infants during the first week of life. STUDY DESIGN:: A retrospective review of 154 ELBWs was conducted. Laboratory and nutritional data from postnatal days 1, 4 and 7 were collected. Repeated measures models estimated the relationship of protein intake with BUN and HCO3 in the first week of life. RESULT:: In total, 359 separate BUN and HCO3 values were analyzed. Each gram per kilogram of protein administered was associated with an increase in mean BUN of 3.3 mg/dl. This effect decreased daily by 2.1mg/dl. Each gram per kilogram of protein administered was associated with a decrease in mean HCO3 by 0.9 mmol/l. CONCLUSION:: The association between protein load and BUN is positive but decreasing over time. Protein is associated with a clinically insignificant decrease in HCO3. Concerns regarding metabolic derangement from early protein administration in ELBWs are unwarranted.