학술논문
Involvement of CD5+CD19+Cell in steroid-dependent nephrotic syndrome treated with B-cell targeting therapy
Document Type
Academic Journal
Source
Pediatrics International. Feb 01, 2013 55(1):99-101
Subject
Language
English
ISSN
1328-8067
Abstract
We showed in this study the longitudinal changes of the B-cell counts in patients with steroid-dependent nephrotic syndrome (SDNS) treated with cyclophosphamide (CPM) and mycophenolate mofetil (MMF). In our case with SDNS, this combined therapy not only decreased B-cell counts but also increased CD5CD19 (CD5B)/ CD5CD19 (CD5-B) cell ratio. Recurrence was not observed when an elevated CD5B/CD5-B cell ratio was maintained even after the B cells increased. Therefore, this ratio might be more important than the whole B-cell counts. The changes of this ratio could be a good predictor of the clinical course of the patients treated with B-cell targeting therapy.