학술논문
Reverse Liver Spleen Uptake on [68Ga]Ga-PSMA-11 PET/CT
Document Type
Academic Journal
Source
Clinical Nuclear Medicine. Dec 01, 2022 47(12):1063-1065
Subject
Language
English
ISSN
0363-9762
Abstract
ABSTRACT: An 80-year-old man underwent [Ga]Ga-PSMA-11 PET/CT for staging of high-risk prostate cancer. Homogeneously increased liver uptake, more than 3-fold the splenic uptake, was seen. There was no hepatic lesion evident on CT. A higher liver to splenic uptake is more typical of some F-labeled PSMA PET/CT but unusual in Ga-labeled PSMA PET/CT scan. Further evaluation revealed a history of impaired renal function, bilateral renal atrophy, relatively decreased renal uptake of [Ga]Ga-PSMA-11, and prominent bowel activity. We concluded that impaired renal function and subsequent poor excretion resulted in increased hepatic excretion, hence the unusual increased homogeneous hepatic uptake.