학술논문
Determination of Measles, Mumps, And Rubella Immunization Status Using Oral Fluid Samples
Document Type
Academic Journal
Source
JAMA The Journal of the American Medical Association. Jul 20, 1994 272(3):219-221
Subject
Language
English
ISSN
0098-7484
Abstract
OBJECTIVE: To determine if oral fluid samples can be used to reliably assess protective blood levels of antibodies to measles, mumps, and rubella. DESIGN: A comparison of matched serum and oral fluid samples from asymptomatic subjects in enzyme-linked immunosorbent assays for measles, mumps, and rubella antibodies. A longitudinal study compared matched serum and oral fluid samples from 11 subjects after measles-mumps-rubella vaccination. SETTING: Five US clinical sites with samples tested at the reporting laboratory. PARTICIPANTS: A total of 157 asymptomatic subjects including 55 subjects younger than 18 years.MAIN OUTCOME MEASURES AND RESULTS-The presence of antibodies in oral fluid specimens correlated with that in serum with the following levels of sensitivity and specificity: measles, 97% and 100%, respectively; mumps, 94% and 94%, respectively; rubella, 98% and 98%, respectively. Longitudinal studies of subjects after vaccination showed similar seroconversion profiles in oral fluid and serum samples. CONCLUSION: Protective blood levels of antibodies to measles, mumps, and rubella can be assessed by means of an oral fluid sample with good reliability.(JAMA. 1994;272:219-221)