학술논문
Apparent prevention of neural tube defects by periconceptional vitamin supplementation*
Document Type
Academic Journal
Author
Source
International Journal of Epidemiology. Oct 01, 2011 40(5):1146-1154
Subject
Language
English
ISSN
0300-5771
Abstract
An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of periconceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1(0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed.