학술논문
IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation
Document Type
Academic Journal
Author
Source
Immunity. May 01, 2013 38(5):958-969
Subject
Language
English
ISSN
1074-7613
Abstract
CD103CD11b dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103CD11b DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103CD11b MLN DCs and DC derived IL-6. Immunized Il6 mice failed to support Th17 cell differentiation in MLN in vivo and CD103CD11b MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103CD11b DCs in intestinal Th17 cell differentiation. GRAPHICAL ABSTRACT: (Figure is included in full-text article.)