학술논문
Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants
Document Type
Academic Journal
Author
van Kaam, Anton H; De Jaegere, Anne P; Rimensberger, Peter C; Debeer, A.; Chemin, A.; Norbert, K.; Autret, F.; Andreou, A.; Kroon, A.; Minić, A.; Schwindt, J.; Brouwers, H.; van Reempts, P.; Hummler, H.; van Veenendaal, M.; Sarafidis, K.; Lopriore, E.; Mosca, F.; McCormick, K.; Schaible, T.; Jaarsma, A.; Polimeni, V.; Plavka, R.; Patkai, J.; Moriette, G.; Valls, A.; Soler, I.; Clarke, P.; Migliori, C.; Hentschel, R.; Sigalas, J.; Ehlen, M.; Fremerey, C.; Roujou-Gris, M.; Stamatin, M.; Mok, Q.; Ata, S.; Günther, M.; Kühr, J.; Seitz, U.; Vermeulen, M.; Knol, R.; Le Bouedec, S.; Szekessy, D.; Wauer, R.; Petropoulou, C.; Moreno Hernando, J.; Jonsson, B.; Mulder, T.; Sweet, D.; Herting, E.; Goepel, W.; Dimitriou, G.; Stuchlíková, H.; Baltogianni, M.; Santillo, V.; Ferrero, F.; Arnault, I.; Dort, J.; Blanc, T.; Rocha, G.; Guimarães, H.; Virella, D.; Costa, A.; Pedro Frutuoso, S.; Biolek, J.; Stoicescu, S.; Schroth, M.; Cirstoveanu, C.; de Boode, W.; Medbo, S.; Müller-Hansen, I.; Poets, C.; Riedel, T.; Palmer, K.; Martano, C.; Stucin Gantar, I.; Biban, P.; Chatfield, S.; Ghesquiere, J.; Theret, B.; Samperiz, S.; Berger, T.; Rigo, V.; Balato, A.; Gresa Munoz, M.; Nunes, A.; Molendijk, H.; Beuger, S.; Puzas, A.; Hiedl, S.; Genzel-Boroviczeny, O.; Anhalt, D.; Möller, J.; Ingemansson, F.; Halbertsma, F.; de Cesaris, V.; Saarela, T.; Karagianni, P.; Tsakalidis, C.; Tølløfsrud, P.; Bougatef, A.; Sindelar, R.; Wisborg, K.; Brink Henriksen, T.; Flumini, C.; Carnielli, V.; Giannuzzo, S.; Dussart, A.; Brault, D.; Samy, M.; van Wien, A.; Cunha, M.; Paulino, E.; Schneider, H.; Sandvoss, A.; Dahlem, P.; Koester, B.; Olhanger, E.; Wentzell, R.; Ramos, C.; Augusta Areias, M.; Verber, I.; Presta, G.; Magaldi, R.; Agostino, R.; Lund, O.; Ulriksen, J.; Steder, U.; Faas, D.; Jensen, R.; Baroutis, G.; Gouder de Beauregard, V.; Zaharie, G.; Eng-Schwartz, A.; Heldmann, M.; Cezanne, T.; Pereira, A.; Nelle, M.; Uxa, F.; Norman, M.; Siegel, J.; Welsch, M.; Schiffmann, H.; Haftel, L.; Wild, F.; Bühr, P.; Simma, B.; Thirumurugan, A.; Mortensen, S.; Ciccotti, R.; Carli, G.; Milligan, D.; Gerleve, H.; Kumararatne, B.; Hakansson, S.; OʼDonovan, D.; Reiterer, F.; Rimensberger, P.; Nietsch, L.; Nakstad, B.; Gancia, P.; Swanstrom, S.; Maton, P.; Cavatorta, E.; Tvarijonoviciene, R.; Hogan, M.; Zinn, P.; Freff, M.; Reigstad, H.; Olariu, G.; Gonçalves, G.; Escumalha, M.; Ornelas, H.; Serrano, A.; Anderssen, S.; Garcia, P.; Mendes Da Graça, A.; Bender, C.; Wald, M.; Bohn, M.; Schnelke, A.; Trips, T.; Ladekjaer, J.; Thompson, F.; Lindberg, E.; Frigerio, M.; Pederzini, F.; De Nisi, G.; Saur, G.; Losa, M.; Toma, A.; Matu, E.; Eckhardt, S.; Bellettato, M.; Fahnenstich, H.; Hetzel, P.; Bland, J.; Øglænd, B.; Lehtonen, L.; Eichler, T.; Roth, M.; Meberg, A.; Kuehn, T.; Emeis, M.
Source
Archives of Disease in Childhood: Fetal and Neonatal Edition. Jul 01, 2013 98(4):F323-F326
Subject
Language
English
ISSN
1359-2998
Abstract
OBJECTIVE: To determine the incidence of hypo- and hyper-capnia in a European cohort of ventilated newborn infants. DESIGN AND SETTING: Two-point cross-sectional prospective study in 173 European neonatal intensive care units. PATIENTS AND METHODS: Patient characteristics, ventilator settings and measurements, and blood gas analyses were collected for endotracheally ventilated newborn infants on two separate dates. RESULTS: A total of 1569 blood gas analyses were performed in 508 included patients with a mean±SD PCO2 of 48±12 mm Hg or 6.4±1.6 kPa (range 17–104 mm Hg or 2.3–13.9 kPa). Hypocapnia (PCO2<30 mm Hg or 4 kPa) and hypercapnia (PCO2>52 mm Hg or 7 kPa) was present in, respectively, 69 (4%) and 492 (31%) of the blood gases. Hypocapnia was most common in the first 3 days of life (7.3%) and hypercapnia after the first week of life (42.6%). PCO2 was significantly higher in preterm infants (49 mm Hg or 6.5 kPa) than term infants (43 mm Hg or 5.7 kPa) and significantly lower during pressure-limited ventilation (47 mm Hg or 6.3±1.6 kPa) compared with volume-targeted ventilation (51 mm Hg or 6.8±1.7 kPa) and high-frequency ventilation (50 mm Hg or 6.7±1.7 kPa). CONCLUSIONS: This study shows that hypocapnia is a relatively uncommon finding during neonatal ventilation. The higher incidence of hypercapnia may suggest that permissive hypercapnia has found its way into daily clinical practice.