학술논문
The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
Document Type
Academic Journal
Author
Elsik, Christine G.; Tellam, Ross L.; Worley, Kim C.; Gibbs, Richard A.; Elsik, Christine G.; Tellam, Ross L; Gibbs, Richard A.; Muzny, Donna M.; Weinstock, George M.; Adelson, David L; Eichler, Evan E.; Elnitski, Laura; Elsik, Christine G.; Guigó, Roderic; Hamernik, Debora L.; Kappes, Steve M.; Lewin, Harris A; Lynn, David J.; Nicholas, Frank W.; Reymond, Alexandre; Rijnkels, Monique; Skow, Loren C.; Tellam, Ross L; Worley, Kim C.; Zdobnov, Evgeny M.; Gibbs, Richard A.; Kappes, Steve M.; Schook, Lawrence; Skow, Loren C.; Weinstock, George M.; Womack, James; Alioto, Tyler; Antonarakis, Stylianos E.; Astashyn, Alex; Chapple, Charles E.; Chen, Hsiu-Chuan; Chrast, Jacqueline; Câmara, Francisco; Elsik, Christine G.; Ermolaeva, Olga; Guigó, Roderic; Henrichsen, Charlotte N.; Hlavina, Wratko; Kapustin, Yuri; Kiryutin, Boris; Kitts, Paul; Kokocinski, Felix; Landrum, Melissa; Maglott, Donna; Pruitt, Kim; Reymond, Alexandre; Sapojnikov, Victor; Searle, Stephen M.; Solovyev, Victor; Souvorov, Alexandre; Ucla, Catherine; Weinstock, George M.; Wyss, Carine; Alioto, Tyler; Antonarakis, Stylianos E.; Chapple, Charles E.; Chrast, Jacqueline; Câmara, Francisco; Guigó, Roderic; Henrichsen, Charlotte N.; Reymond, Alexandre; Ucla, Catherine; Wyss, Carine; Anzola, Juan M.; Gerlach, Daniel; Zdobnov, Evgeny M.; Elhaik, Eran; Elsik, Christine G.; Graur, Dan; Reese, Justin T.; Adelson, David L.; Edgar, Robert C.; McEwan, John C.; Payne, Gemma M.; Raison, Joy M.; Junier, Thomas; Kriventseva, Evgenia V.; Zdobnov, Evgeny M.; Chrast, Jacqueline; Eyras, Eduardo; Henrichsen, Charlotte N.; Plass, Mireya; Reymond, Alexandre; Donthu, Ravikiran; Larkin, Denis M.; Lewin, Harris A.; Nicholas, Frank W.; Elnitski, Laura; Larkin, Denis M.; Lewin, Harris A.; Reecy, James; Yang, Mary Q.; Adelson, David L; Chen, Lin; Cheng, Ze; Chitko-McKown, Carol G.; Eichler, Evan E.; Elnitski, Laura; Elsik, Christine G.; Liu, George E.; Matukumalli, Lakshmi K.; Song, Jiuzhou; Zhu, Bin; Elsik, Christine G.; Lynn, David J.; Reese, Justin T.; Bradley, Daniel G.; Brinkman, Fiona S.L; Lau, Lilian P.L.; Lynn, David J.; Whiteside, Matthew D.; Tellam, Ross L; Walker, Angela; Wheeler, Thomas T.; Casey, Theresa; German, Bruce J.; Lemay, Danielle G.; Lynn, David J.; Maqbool, Nauman J.; Molenaar, Adrian J.; Rijnkels, Monique; Lewin, Harris A.; Seo, Seongwon; Stothard, Paul; Baldwin, Cynthia L.; Baxter, Rebecca; Brinkmeyer-Langford, Candice L.; Brown, Wendy C.; Childers, Christopher P.; Connelley, Timothy; Ellis, Shirley A.; Fritz, Krista; Glass, Elizabeth J.; Herzig, Carolyn T.A.; livanainen, Antti; Lahmers, Kevin K.; Skow, Loren C.; Bennett, Anna K.; Childers, Christopher P.; Dickens, Michael C.; Elsik, Christine G.; Gilbert, James G.R.; Hagen, Darren E.; Reese, Justin T.; Salih, Hanni; Aerts, Jan; Caetano, Alexandre R.; Dalrymple, Brian; Elsik, Christine G.; Fernando Garcia, Jose; Gibbs, Richard A.; Gill, Clare A.; Hamernik, Debora L; Hiendleder, Stefan G.; Memili, Erdogan; Nicholas, Frank W.; Reecy, James; Rijnkels, Monique; Skow, Loren C.; Spurlock, Diane; Stothard, Paul; Tellam, Ross L; Weinstock, George M.; Williams, John L; Worley, Kim C.; Alexander, Lee; Brownstein, Michael J.; Guan, Leluo; Holt, Robert A.; Jones, Steven J.M.; Marra, Marco A.; Moore, Richard; Moore, Stephen S.; Roberts, Andy; Taniguchi, Masaaki; Waterman, Richard C.; Chacko, Joseph; Chandrabose, Mimi M.; Cree, Andy; Diep Dao, Marvin; Dinh, Huyen H.; Ayiesha Gabisi, Ramatu; Hines, Sandra; Hume, Jennifer; Jhangiani, Shalini N.; Joshi, Vandita; Kovar, Christie L.; Lewis, Lora R.; Liu, Yih-shin; Lopez, John; Morgan, Margaret B.; Muzny, Donna M.; Bich Nguyen, Ngoc; Okwuonu, Geoffrey O.; Ruiz, San Juana; Santibanez, Jireh; Wright, Rita A.; Buhay, Christian; Ding, Yan; Dugan-Rocha, Shannon; Herdandez, Judith; Holder, Michael; Sabo, Aniko; Egan, Amy; Goodell, Jason; Wilczek-Boney, Katarzyna; Fowler, Gerald R.; Edward Hitchens, Matthew; Lozado, Ryan J.; Moen, Charles; Steffen, David; Warren, James T.; Zhang, Jingkun; Chiu, Readman; Jones, Steven J.M.; Marra, Marco A.; Schein, Jacqueline E.; James Durbin, K.; Havlak, Paul; Jiang, Huaiyang; Liu, Yue; Qin, Xiang; Ren, Yanru; Shen, Yufeng; Song, Henry; Weinstock, George M.; Worley, Kim C.; Nicole Bell, Stephanie; Davis, Clay; Jolivet Johnson, Angela; Lee, Sandra; Nazareth, Lynne V.; Patel, Bella Mayurkumar; Pu, Ling-Ling; Vattathil, Selina; Williams, Rex Lee, Jr.; Curry, Stacey; Hamilton, Cerissa; Sodergren, Erica; Nazareth, Lynne V.; Wheeler, David A.; Adelson, David L; Aerts, Jan; Barris, Wes; Bennett, Gary L; Dalrymple, Brian; Eggen, André; Gill, Clare A.; Green, Ronnie D.; Harhay, Gregory P.; Hobbs, Matthew; Jann, Oliver; Kappes, Steve M.; Keele, John W.; Kent, Matthew P.; Larkin, Denis M.; Lewin, Harris A.; Lien, Sigbjørn; McEwan, John C.; McKay, Stephanie D.; McWilliam, Sean; Moore, Stephen S.; Nicholas, Frank W.; Payne, Gemma M.; Ratnakumar, Abhirami; Salih, Hanni; Schnabel, Robert D.; Smith, Timothy; Snelling, Warren M.; Sonstegard, Tad S.; Stone, Roger T.; Sugimoto, Yoshikazu; Takasuga, Akiko; Taylor, Jeremy F.; Tellam, Ross L.; Van Tassell, Curtis P.; Williams, John L; MacNeil, Michael D.; Abatepaulo, Antonio R.R.; Abbey, Colette A.; Aerts, Jan; Ahola, Virpi; Almeida, Iassudara G.; Amadio, Ariel F.; Anatriello, Elen; Bahadue, Suria M.; Baldwin, Cynthia L.; Baxter, Rebecca; Bennett, Anna K.; Biase, Fernando H.; Boldt, Clayton R.; Brinkmeyer-Langford, Candice L; Brown, Wendy C.; Caetano, Alexandre R.; Carroll, Jeffery A.; Carvalho, Wanessa A; Casey, Theresa; Cervelatti, Eliane P.; Chacko, Elsa; Chapin, Jennifer E.; Cheng, Ye; Childers, Christopher P.; Choi, Jungwoo; Colley, Adam J.; Connelley, Timothy; de Campos, Tatiana A.; De Donato, Marcos; de Miranda Santos, Isabel K.F.; de Oliveira, Carlo J.F.; Deobald, Heather; Devinoy, Eve; Dickens, Michael C.; Donohue, Kaitlin E.; Dovc, Peter; Eberlein, Annett; Ellis, Shirley A.; Fitzsimmons, Carolyn J.; Franzin, Alessandra M.; Fritz, Krista; Garcia, Gustavo R.; Fernando Garcia, Jose; Genini, Sem; German, Bruce J.; Gilbert, James G.R.; Gill, Clare A.; Gladney, Cody J.; Glass, Elizabeth J.; Grant, Jason R.; Greaser, Marion L.; Green, Jonathan A.; Hadsell, Darryl L.; Hagen, Darren E.; Hakimov, Hatam A.; Halgren, Rob; Harrow, Jennifer L; Hart, Elizabeth A.; Hastings, Nicola; Hernandez, Marta; Herzig, Carolyn T.A.; Hiendleder, Stefan G.; Hobbs, Matthew; Hu, Zhi-Liang; livanainen, Antti; Ingham, Aaron; Iso-Touru, Terhi; Jamis, Catherine; Jann, Oliver; Jensen, Kirsty; Kapetis, Dimos; Kerr, Tovah; Khalil, Sari S.; Khatib, Hasan; Kolbehdari, Davood; Kumar, Charu G.; Kumar, Dinesh; Leach, Richard; Lee, Justin C-M; Lemay, Danielle G.; Li, Changxi; Liu, George E.; Logan, Krystin M.; Malinverni, Roberto; Maqbool, Nauman J.; Marques, Elisa; Martin, William F.; Martins, Natalia F.; Maruyama, Sandra R.; Mazza, Raffaele; McLean, Kim L; Medrano, Juan F.; Memili, Erdogan; Molenaar, Adrian J.; Moreno, Barbara T.; Moré, Daniela D.; Muntean, Carl T.; Nandakumar, Hari P.; Nogueira, Marcelo F.G.; Olsaker, Ingrid; Pant, Sameer D.; Panzitta, Francesca; Pastor, Rosemeire C.P.; Poli, Mario A.; Poslusny, Nathan; Rachagani, Satyanarayana; Ranganathan, Shoba; Razpet, Andrej; Reecy, James; Riggs, Penny K.; Rijnkels, Monique; Rincon, Gonzalo; Rodriguez-Osorio, Nelida; Rodriguez-Zas, Sandra L.; Romero, Natasha E.; Rosenwald, Anne; Sando, Lillian; Schmutz, Sheila M.; Seo, Seongwon; Shen, Libing; Sherman, Laura; Skow, Loren C.; Southey, Bruce R.; Spurlock, Diane; Strandberg Lutzow, Ylva; Sweedler, Jonathan V.; Tammen, Imke; Taniguchi, Masaaki; Tellam, Ross L; Telugu, Bhanu Prakash V.L; Urbanski, Jennifer M.; Utsunomiya, Yuri T.; Verschoor, Chris P.; Waardenberg, Ashley J.; Walker, Angela; Wang, Zhiquan; Ward, Robert; Weikard, Rosemarie; Welsh, Thomas H., Jr.; Wheeler, Thomas T.; White, Stephen N.; Williams, John L; Wilming, Laurens G.; Wunderlich, Kris R.; Yang, Jianqi; Zhao, Feng-Qi
Source
Science. Apr 24, 2009 324(5926):522-528
Subject
Language
English
ISSN
0036-8075
Abstract
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.