학술논문
CD3ζ Expression and T Cell Proliferation are Inhibited by TGF-β1 and IL-10 in Cervical Cancer Patients
Document Type
Academic Journal
Author
Díaz-Benítez, Cinthya E.; Navarro-Fuentes, Karla R.; Flores-Sosa, Jacqueline A.; Juárez-Díaz, Janet; Uribe-Salas, Felipe J.; Román-Basaure, Edgar; González-Mena, Ludwig E.; de Ruíz, Patricia Alonso; López-Estrada, Guillermina; Lagunas-Martínez, Alfredo; Bermúdez-Morales, Victor H.; Alcocer-González, Juan M.; Martínez-Barnetche, Jesús; Hernández-Pando, Rogelio; Rosenstein, Yvonne; Moreno, José; Madrid-Marina, Vicente
Source
Journal of Clinical Immunology. Jul 01, 2009 29(4):532-544
Subject
Language
English
ISSN
0271-9142
Abstract
INTRODUCTION: Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3ζ expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC). RESULTS AND DISCUSSION: T cell proliferation and cytokine messenger RNA (mRNA) expression were similar in women with SIL and healthy donors, whereas low T cell proliferation and lower mRNA expression of IL-2, IL-10 and IFN-γ were observed in women with CC. Moreover, infiltrating cells showed marginal responses. We also found that CD3ζ mRNA expression, whose protein is required for T cell activation, correlated with a decreased proliferation in advanced stages of the disease. CONCLUSION: Experiments with T cells from healthy donors in the presence TGF-β1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during CC progression.