학술논문
Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva
Document Type
Academic Journal
Author
Pain, Arnab; Renauld, Hubert; Berriman, Matthew; Murphy, Lee; Yeats, Corin A.; Weir, William; Kerhornou, Arnaud; Aslett, Martin; Bishop, Richard; Bouchier, Christiane; Cochet, Madeleine; Coulson, Richard M.R.; Cronin, Ann; de Villiers, Etienne P.; Fraser, Audrey; Fosker, Nigel; Gardner, Malcolm; Goble, Arlette; Griffiths-Jones, Sam; Harris, David E.; Katzer, Frank; Larke, Natasha; Lord, Angela; Maser, Pascal; McKellar, Sue; Mooney, Paul; Morton, Fraser; Nene, Vishvanath; O'Neil, Susan; Price, Claire; Quail, Michael A.; Rabbinowitsch, Ester; Rawlings, Neil D.; Rutter, Simon; Saunders, David; Seeger, Kathy; Shah, Trushar; Squares, Robert; Squares, Steven; Tivey, Adrian; Walker, Alan R.; Woodward, John; Dobbelaere, Dirk A. E.; Langsley, Gordon; Rajandream, Marie-Adele; McKeever, Declan; Shiels, Brian; Tait, Andrew; Barrell, Bart; Hall, Neil
Source
Science. Jul 01, 2005 309(5731):131-133
Subject
Language
English
ISSN
0036-8075
Abstract
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.