학술논문
Characterization of SR 121463A, a Highly Potent and Selective, Orally Active Vasopressin V sub 2 Receptor Antagonist
Document Type
Academic Journal
Author
Serradeil-Le Gal, Claudine; Lacour, Colette; Valette, Gerard; Garcia, Georges; Foulon, Loic; Galindo, Gerard; Bankir, Lise; Pouzet, Brigitte; Guillon, Gilles; Barberis, Claude; Chicot, Danielle; Jard, Serge; Vilain, Pol; Garcia, Corine; Marty, Eleonore; Raufaste, Danielle; Brossard, Gabrielle; Nisato, Dino; Maffrand, Jean Pierre; Le Fur, Gerard
Source
The Journal of Clinical Investigation. Dec 15, 1996 98(12):2729-2738
Subject
Language
English
ISSN
0021-9738
Abstract
SR 121463A, a potent and selective, orally active, nonpeptide vasopressin V sub 2 receptor antagonist, has been characterized in several in vitro and in vivo models. This compound displayed highly competitive and selective affinity for V2 receptors in rat, bovine and human kidney (0.6