학술논문
Normal Taste Acceptance and Preference of PANX1 Knockout Mice
Document Type
Academic Journal
Author
Source
Chemical Senses. Sep 01, 2015 40(7):453-459
Subject
Language
English
ISSN
0379-864X
Abstract
Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.