학술논문
Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment
Document Type
Academic Journal
Author
de Souto Barreto, Philipe; Andrieu, Sandrine; Payoux, Pierre; Demougeot, Laurent; Rolland, Yves; Vellas, Bruno; Gillette-Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Cantet, Christelle; Gardette, Virginie; Morin, Christophe; Kan, Gabor Abellan Van; Dupuy, Charlotte; Caillaud, Céline; Ousset, Pierre-Jean; Willis, Sherry; Belleville, Sylvie; Gilbert, Brigitte; Fontaine, Francine; Dartigues, Jean-François; Marcet, Isabelle; Delva, Fleur; Foubert, Alexandra; Cerda, Sandrine; Cuffi, Marie-Noëlle; Costes, Corinne; Rouaud, Olivier; Manckoundia, Patrick; Quipourt, Valérie; Marilier, Sophie; Franon, Evelyne; Bories, Lawrence; Pader, Marie-Laure; Basset, Marie-France; Lapoujade, Bruno; Faure, Valérie; Tong, Michael Li Yung; Malick-Loiseau, Christine; Cazaban-Campistron, Evelyne; Desclaux, Françoise; Blatge, Colette; Dantoine, Thierry; Laubarie-Mouret, Cécile; Saulnier, Isabelle; Clément, Jean-Pierre; Picat, Marie-Agnès; Bernard-Bourzeix, Laurence; Willebois, Stéphanie; Désormais, Iléana; Cardinaud, Noëlle; Bonnefoy, Marc; Livet, Pierre; Rebaudet, Pascale; Gédéon, Claire; Burdet, Catherine; Terracol, Flavien; Pesce, Alain; Roth, Stéphanie; Chaillou, Sylvie; Louchart, Sandrine; Sudres, Kristelle; Lebrun, Nicolas; Barro-Belaygues, Nadège; Touchon, Jacques; Bennys, Karim; Gabelle, Audrey; Romano, Aurélia; Touati, Lynda; Marelli, Cécilia; Pays, Cécile; Robert, Philippe; Duff, Franck Le; Gervais, Claire; Gonfrier, Sébastien; Gasnier, Yves; Bordes, Serge; Begorre, Danièle; Carpuat, Christian; Khales, Khaled; Lefebvre, Jean-François; Idrissi, Samira Misbah El; Skolil, Pierre; Salles, Jean-Pierre; Dufouil, Carole; Lehéricy, Stéphane; Chupin, Marie; Mangin, Jean-François; Bouhayia, Ali; Allard, Michèle; Ricolfi, Frédéric; Dubois, Dominique; Martel, Marie Paule Bonceour; Cotton, François; Bonafé, Alain; Chanalet, Stéphane; Hugon, Françoise; Bonneville, Fabrice; Cognard, Christophe; Chollet, François; Voisin, Thierry; Peiffer, Sophie; Hitzel, Anne; Zanca, Michel; Monteil, Jacques; Darcourt, Jacques; Molinier, Laurent; Derumeaux, Hélène; Costa, Nadège; Vincent, Christian; Perret, Bertrand; Vinel, Claire; Savy, S; Coley, N
Source
Journal of the American Geriatrics Society. Aug 01, 2015 63(8):1634-1639
Subject
Language
English
ISSN
0002-8614
Abstract
OBJECTIVES:: To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN:: Cross-sectional study. SETTING:: French community-dwelling people. PARTICIPANTS:: Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268). MEASUREMENTS:: A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR−). RESULTS:: Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR− participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function. CONCLUSION:: Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimerʼs disease.