학술논문
68Ga-DOTATOC Pictorial Essay of Various Recurrent Meningiomas Rejected for Treatment With 177Lu-DOTATATE: Is There a Place for Another Theranostic Examination?
Document Type
Academic Journal
Source
Clinical Nuclear Medicine. Jul 01, 2024 49(7):655-658
Subject
Language
English
ISSN
0363-9762
Abstract
ABSTRACT: We report the cases of 4 patients treated for recurrent meningiomas of various grades. Pretreatment Ga-DOTATOC PET/CT was performed prior to screening for vectorized internal radiotherapy with Lu-DOTATATE or prior external radiotherapy to aid contouring. None of these patients had sufficient uptake to be eligible for Lu-DOTATATE or reliable contouring. Most recurrences were grades II and III, suggesting a loss of physiological somatostatin receptor overexpression in these tumors. Therefore, the benefit of treatment with Lu-DOTATATE in the current indication is questionable. In the absence of a validated systemic treatment, and considering a few case reports, treatment with Lu-PSMA could be investigated as an additional vectorized internal radiotherapy option.