부산대학교 도서관

INTRODUCTION:: Given the altered physiology of pregnancy, gastroenterologists are often reluctant to perform endoscopic procedures in pregnant women. The purpose of our study was to compare management practices and outcomes among pregnant and non-pregnant women admitted to the hospital for peptic ulcer disease (PUD). METHODS:: A retrospective matched cohort study was carried out using the Healthcare Cost and Utilization Project—National Inpatient Sample. All births that took place from 1999 to 2015 were identified and women were classified as having PUD on the basis of ICD-9 coding. Logistic regression analysis was used to evaluate the adjusted effect of PUD on variables and outcomes of interest. RESULTS:: PUD was diagnosed in 2,535 pregnant women and 12,675 age-matched non-pregnant women during the 16-year study period. Compared with non-pregnant women, pregnant women were more likely to be Hispanic, less likely to be Caucasian and less likely to be smokers. As compared to non-pregnant women, pregnant women with PUD were less likely to undergo diagnostic or therapeutic esophagogastroduodenoscopies for this indication. Outcomes including fever, infection, sepsis, shock, transfusion and death were less likely to occur in pregnant women as compared to non-pregnant women and pregnant women also experienced shorter hospital stays. CONCLUSION:: Pregnant women with PUD are less likely to undergo interventional diagnostic and therapeutic procedures than non-pregnant women with PUD. The reluctance to intervene in pregnancy does not appear to result in more adverse PUD-associated outcomes.