학술논문
Coagulation and inflammation biomarkers may help predict the severity of community-acquired pneumonia
Document Type
Academic Journal
Author
Source
Respirology. Jul 01, 2010 15(5):796-803
Subject
Language
English
ISSN
1323-7799
Abstract
BACKGROUND AND OBJECTIVE:: METHODS:: RESULTS:: Forty patients (52%) had severe CAP (CURB-65 score 3–5). Serum levels of AT-III were lower and levels of D-D and CRP were higher in patients with severe CAP than in patients with mild CAP (CURB-65 score 0–2) (P < 0.001 for all comparisons). Levels of P-C were lower in patients with severe CAP compared with those with mild CAP, but the difference was not significant (P = 0.459). At a cut-off point of 85%, AT-III showed a sensitivity of 80% and a specificity of 75%, as a determinant of the need for hospitalization. At a cut-off point of 600 ng/mL, D-D showed a sensitivity of 90% and a specificity of 75% and at a cut-off point of 110 mg/L, CRP showed a sensitivity of 83% and a specificity of 79%, as determinants of the need for hospitalization. CONCLUSIONS