부산대학교 도서관

BACKGROUND:: Cerebral palsy is the most common cause of pediatric-onset dystonia. Deep brain stimulation is gaining acceptance for treating dystonias in children. There is minimal reported experience regarding the efficacy of deep brain stimulation in cerebral palsy. METHODS:: Fourteen patients, including 8 younger than 16 years, received bilateral implants (13 patients) or a unilateral implant (1 patient) of the internal globus pallidus and were observed in a noncontrolled, nonblinded study for at least 6 months. Motor function was assessed using the Burke-Fahn-Marsden Dystonia Movement and Disability scales and the Barry Albright Dystonia Scale. RESULTS:: By 6 months, significant improvement was observed in the Burke-Fahn-Marsden Dystonia Movement scale (P = .004), the Burke-Fahn-Marsden Dystonia Disability scale (P = .027), and the Barry Albright Dystonia Scale (P = .029) for the whole cohort (n = 14) and in the patients treated before skeletal maturity (group 1; n = 8): Burke-Fahn-Marsden Dystonia Movement scale, P = .012; Burke-Fahn-Marsden Dystonia Disability scale, P = .020; and Barry Albright Dystonia Scale, P = .027. CONCLUSIONS:: Deep brain stimulation may offer an effective treatment option for cerebral palsy–related dystonia, especially in those treated before skeletal maturity.