학술논문
Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort
Document Type
Academic Journal
Author
Aronsson, Carin Andrén; Lee, Hye-Seung; Koletzko, Sibylle; Uusitalo, Ulla; Yang, Jimin; Virtanen, Suvi M.; Liu, Edwin; Lernmark, Åke; Norris, Jill M.; Agardh, Daniel; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Bedoy, Ruth; Felipe-Morales, Daniel; Frohnert, Brigitte I.; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Liu, Edwin; Norris, Jill; Samper-Imaz, Adela; Steck, Andrea; Waugh, Kathleen; Wright, Hali; She, Jin-Xiong; Schatz, Desmond; Hopkins, Diane; Steed, Leigh; Thomas, Jamie; Adams, Janey; Silvis, Katherine; Haller, Michael; Gardiner, Melissa; McIndoe, Richard; Sharma, Ashok; Williams, Joshua; Foghis, Gabriela; Anderson, Stephen W.; Robinson, Richard; Ziegler, Anette G.; Beyerlein, Andreas; Bonifacio, Ezio; Hummel, Michael; Hummel, Sandra; Foterek, Kristina; Kersting, Mathilde; Knopff, Annette; Koletzko, Sibylle; Peplow, Claudia; Roth, Roswith; Stock, Joanna; Strauss, Elisabeth; Warncke, Katharina; Winkler, Christiane; Toppari, Jorma; Simell, Olli G.; Adamsson, Annika; Hyöty, Heikki; Ilonen, Jorma; Jokipuu, Sanna; Kallio, Tiina; Kähönen, Miia; Knip, Mikael; Koivu, Annika; Koreasalo, Mirva; Kurppa, Kalle; Lönnrot, Maria; Mäntymäki, Elina; Multasuo, Katja; Mykkänen, Juha; Niininen, Tiina; Nyblom, Mia; Rajala, Petra; Rautanen, Jenna; Riikonen, Anne; Romo, Minna; Simell, Satu; Simell, Tuula; Simell, Ville; Sjöberg, Maija; Stenius, Aino; Särmä, Maria; Vainionpää, Sini; Varjonen, Eeva; Veijola, Riitta; Virtanen, Suvi M.; Vähä-Mäkilä, Mari; Åkerlund, Mari; Lernmark, Åke; Agardh, Daniel; Ask, Maria; Bremer, Jenny; Carlsson, Ulla-Marie; Cilio, Corrado; Ericson-Hallström, Emelie; Fransson, Lina; Gard, Thomas; Gerardsson, Joanna; Bennet, Rasmus; Hansen, Monica; Hansson, Gertie; Harmby, Cecilia; Hyberg, Susanne; Johansen, Fredrik; Jonasdottir, Berglind; Larsson, Helena Elding; Forss, Sigrid Lenrick; Lundgren, Markus; Månsson-Martinez, Maria; Markan, Maria; Melin, Jessica; Mestan, Zeliha; Rahmati, Kobra; Ramelius, Anita; Rosenquist, Anna; Salami, Falastin; Sibthorpe, Sara; Sjöberg, Birgitta; Swartling, Ulrica; Amboh, Evelyn Tekum; Trulsson, Erika; Törn, Carina; Wallin, Anne; Wimar, Åsa; Åberg, Sofie; Hagopian, William A.; Killian, Michael; Crouch, Claire Cowen; Skidmore, Jennifer; Ayres, Stephen; Dunson, Kayleen; Hervey, Rachel; Johnson, Corbin; Lyons, Rachel; Meyer, Arlene; Mulenga, Denise; Scott, Elizabeth; Stabbert, Joshua; Tarr, Alexander; Uland, Morgan; Willis, John; Becker, Dorothy; Franciscus, Margaret; Smith, MaryEllen Dalmagro-Elias; Daftary, Ashi; Klein, Mary Beth; Yates, Chrystal; Krischer, Jeffrey P.; Abbondondolo, Michael; Austin-Gonzalez, Sarah; Baethke, Sandra; Brown, Rasheedah; Burkhardt, Brant; Butterworth, Martha; Clasen, Joanna; Cuthbertson, David; Eberhard, Christopher; Fiske, Steven; Garcia, Dena; Garmeson, Jennifer; Gowda, Veena; Heyman, Kathleen; Laras, Francisco Perez; Lee, Hye-Seung; Liu, Shu; Liu, Xiang; Lynch, Kristian; Malloy, Jamie; McCarthy, Cristina; McLeod, Wendy; Meulemans, Steven; Shaffer, Chris; Smith, Laura; Smith, Susan; Sulman, Noah; Tamura, Roy; Uusitalo, Ulla; Vehik, Kendra; Vijayakandipan, Ponni; Wood, Keith; Yang, Jimin; Ballard, Lori; Hadley, David; Akolkar, Beena; Bourcier, Kasia; Briese, Thomas; Johnson, Suzanne Bennett; Triplett, Eric
Source
Clinical Gastroenterology & Hepatology. Mar 01, 2016 14(3):403-409e3
Subject
Language
English
ISSN
1542-3565
Abstract
BACKGROUND & AIMS:: METHODS:: RESULTS:: Breastfeeding duration (median, 32 wk) and age at first introduction to gluten (median, 22 wk) did not differ between cases and tTGA-negative controls. At the visit before tTGA seroconversion, cases reported a larger intake of gluten than controls (OR, 1.28; 95% confidence interval [CI], 1.13–1.46; P = .0002). More cases than controls were found in the upper third tertile (ie, >5.0 g/d) before they tested positive for tTGA seroconversion than controls (OR, 2.65; 95% CI, 1.70–4.13; P < .0001). This finding was similar in children homozygous for DR3-DQ2 (OR, 3.19; 95% CI, 1.61–6.30; P = .001), heterozygous for DR3-DQ2 (OR, 2.24; 95% CI, 1.08-4.62; P = .030), and for children not carrying DR3-DQ2 (OR, 2.43; 95% CI, 0.90–6.54; P = .079). CONCLUSIONS