학술논문
Clonal Abundance of Tumor-Specific CD4+ T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion
Document Type
Academic Journal
Author
Source
Immunity. Jan 01, 2016 44(1):179-193
Subject
Language
English
ISSN
1074-7613
Abstract
GRAPHICAL ABSTRACT: (Figure is included in full-text article.) HIGHLIGHTS: : Self-reactive tumor-specific CD4 T cells are eliminated from the immune repertoire during negative selection. Wolchok and colleagues demonstrate that the clonal abundance of melanocyte-specific CD4 T cells instructs the development effector function and shapes the potential for T cell exhaustion with profound effects on anti-tumor efficacy.