학술논문
Target-determined expression of α3 isoform of the Na+,K+-ATPase in the somatic nervous system of rat
Document Type
Academic Journal
Source
Journal of Comparative Neurology. Feb 28, 2005 483(1):114-123
Subject
Language
English
ISSN
0021-9967
Abstract
Factors that determine the differential expression of isoforms of Na,K-ATPase in the nervous system of vertebrates are not understood. To address this question we studied the expression of α3 Na,K-ATPase in the L5 dorsal root ganglia (DRG) of developing rat, the normal adult rat, and the adult rat after peripheral axotomy. During development, the first α3 Na,K-ATPase-positive DRG neurons appear by embryonic day 21. At birth, the L5 DRG have a full complement (14 ± 2%) of these neurons. By 15 days after sciatic nerve transection in adult rat, the number of α3 Na,K-ATPase-positive DRG neurons and small myelinated L5 ventral root axons decreases to about 35% of control counts. These results combined with data from the literature suggest that the expression of α3 Na,K-ATPase by rat somatic neurons is determined by target-muscle spindle-derived factors. J. Comp. Neurol. 483:114–123, 2005. © 2005 Wiley-Liss, Inc.