학술논문
Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: studies in a rat stroke model
Document Type
Academic Journal
Author
Source
International Journal of Stroke. Jun 01, 2015 10(4):553-559
Subject
Language
English
ISSN
1747-4930
Abstract
BACKGROUND: AIMS: METHODS: Permanent middle cerebral artery occlusion was performed in adult outbred Wistar rats (n = 6) and serial perfusion computed tomography scans were taken every 30 mins for 2 h. To define infarction thresholds at 1 h and 2 h post-stroke, separate groups of rats underwent 1 h (n = 6) and 2 h (n = 6) of middle cerebral artery occlusion followed by reperfusion. Infarct volumes were defined by histology at 24 h. Co-registration with perfusion computed tomography maps (cerebral blood flow, cerebral blood volume, and mean transit time) permitted pixel-based analysis of thresholds defining infarction, using receiver operating characteristic curves. RESULTS: CONCLUSIONS