학술논문
Short-duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise
Document Type
Academic Journal
Author
Source
International Journal of Stroke. Jul 01, 2014 9(5):553-559
Subject
Language
English
ISSN
1747-4930
Abstract
BACKGROUND: HYPOTHESES: METHODS: RESULTS: In Long-Evans rats (n = 5), intracranial pressure increased from 10·9 ± 4·6 mmHg at baseline to 32·4 ± 11·4 mmHg at 24 h, infarct volume was 84·3 ± 15·9 mm. In normothermic Wistars (n = 10), intracranial pressure increased from 6·7 ± 2·3 mmHg to 31·6 ± 9·3 mmHg, infarct volume was 31·3 ± 18·4 mm. In hypothermia-treated Wistars (n = 10), 24 h intracranial pressure did not increase (7·0 ± 2·8 mmHg, P < 0·001 vs. normothermia), and infarct volume was smaller (15·4 ± 11·8 mm, P < 0·05). CONCLUSIONS