학술논문
HIV-2 viral tropism influences CD4+ T cell count regardless of viral load
Document Type
Academic Journal
Author
Treviño, Ana; Soriano, Vicente; Poveda, Eva; Parra, Patricia; Cabezas, Teresa; Caballero, Estrella; Roc, Lourdes; Rodríguez, Carmen; Eiros, Jose M.; Lopez, Mariola; De Mendoza, Carmen; Rodríguez, C.; del Romero, J.; Tuset, C.; Marcaida, G.; Ocete, M. D.; Tuset, T.; Caballero, E.; Molina, I.; Aguilera, A.; Rodríguez-Calviño, J. J.; Navarro, D.; Regueiro, B.; Benito, R.; Gil, J.; Borrás, M.; Ortiz de Lejarazu, R.; Eiros, J. M.; Manzardo, C.; Miró, J. M.; García, J.; Paz, I.; Calderón, E.; Leal, M.; Vallejo, A.; Abad, M.; Dronda, F.; Moreno, S.; Escudero, D.; Trigo, M.; Diz, J.; Álvarez, P.; Cortizo, S.; García-Campello, M.; Rodríguez-Iglesias, M.; Hernández-Betancor, A.; Martín, A. M.; Ramos, J. M.; Gutiérrez, F.; Rodríguez, J. C.; Gómez-Hernando, C.; Guelar, A.; Cilla, G.; Pérez-Trallero, E.; López-Aldeguer, J.; Sola, J.; Fernández-Pereira, L.; Niubó, J.; Hernández, M.; López-Lirola, A. M.; Gómez-Sirvent, J. L.; Force, L.; Cifuentes, C.; Pérez, S.; Morano, L.; Raya, C.; González-Praetorius, A.; Pérez, J. L.; Peñaranda, M.; Mena, A.; Montejo, J. M.; Roc, L.; Martinez-Sapiña, A.; Viciana, I.; Cabezas, T.; Lozano, A.; Fernández, J. M.; García Bermejo, I.; Gaspar, G.; García, R.; Górgolas, M.; Miralles, P.; Aldamiz, T.; García, F.; Suárez, A.; Treviño, A.; Parra, P.; de Mendoza, C.; Soriano, V.
Source
Journal of Antimicrobial Chemotherapy. Aug 01, 2014 69(8):2191-2194
Subject
Language
English
ISSN
0305-7453
Abstract
BACKGROUND: HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in comparison with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails to provide optimal CD4 recovery. METHODS: We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viral tropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA. RESULTS: From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3 sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%). Patients with X4 viruses had lower median CD4+ cell counts than patients with R5 viruses [130 (17–210) versus 359 (180–470) cells/mm; P = 0.007]. This was true even considering only the subset of 19 patients on antiretroviral therapy [94 (16–147) versus 184 (43–368) cells/mm; P = 0.041]. In multivariate analysis, significant differences in CD4+ cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender, antiretroviral therapy and viral load. CONCLUSIONS: The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+ cell counts, regardless of antiretroviral treatment. Along with CD4+ cell counts, viral tropism testing may assist decisions about when to initiate antiretroviral therapy in HIV-2-infected individuals.