학술논문
Clinical Benefit of Intravascular Imaging Compared With Conventional Angiography in Left Main Coronary Artery Intervention
Document Type
Academic Journal
Author
Kwon, Woochan; Lee, Joo Myung; Yun, Kyeong Ho; Choi, Ki Hong; Lee, Seung-Jae; Lee, Jong-Young; Lee, Sang Yeub; Kim, Sang Min; Cho, Jae Young; Kim, Chan Joon; Ahn, Hyo-Suk; Nam, Chang-Wook; Yoon, Hyuck-Jun; Park, Yong Hwan; Lee, Wang Soo; Jeong, Jin-Ok; Song, Pil Sang; Doh, Joon-Hyung; Jo, Sang-Ho; Yoon, Chang-Hwan; Kang, Min Gyu; Koh, Jin-Sin; Lee, Kwan Yong; Lim, Young-Hyo; Cho, Yun-Hyeong; Cho, Jin-Man; Jang, Woo Jin; Chun, Kook-Jin; Hong, David; Park, Taek Kyu; Yang, Jeong Hoon; Choi, Seung-Hyuk; Gwon, Hyeon-Cheol; Hahn, Joo-Yong; Song, Young Bin
Source
Circulation: Cardiovascular Interventions. Dec 01, 2023 16(12):e013359-e013359
Subject
Language
English
ISSN
1941-7632
Abstract
BACKGROUND:: The RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance Versus Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention) demonstrated that intravascular imaging–guided percutaneous coronary intervention (PCI) improved clinical outcome compared with angiography-guided PCI for patients with complex coronary artery lesions. This study aims to assess whether the prognostic benefit of intravascular imaging–guided procedural optimization persists in patients undergoing PCI for left main coronary artery disease. METHODS:: Of 1639 patients enrolled in the RENOVATE-COMPLEX-PCI, 192 patients with left main coronary artery disease were selected for the current prespecified substudy. Selected patients were randomly assigned to either the intravascular imaging–guided PCI group (n=138) or the angiography-guided PCI group (n=54). The primary end point was target vessel failure defined as a composite of cardiac death, target vessel–related myocardial infarction, or clinically driven target vessel revascularization. RESULTS:: At a median follow-up of 2.1 years (interquartile range 1.1 to 3.0 years), intravascular imaging–guided PCI was associated with lower incidence of primary end point compared with angiography-guided PCI (6.8% versus 25.1%; hazard ratio, 0.31 [95% CI, 0.13–0.76]; P=0.010). This significant reduction in primary end point was mainly driven by a lower risk of cardiac death or spontaneous target vessel–related myocardial infarction (1.6% versus 12.7%; hazard ratio, 0.16 [95% CI, 0.03–0.82]; P=0.028). Intravascular imaging–guided PCI was independently associated with a lower risk of primary end point, even after adjusting for various clinical factors (hazard ratio, 0.29 [95% CI, 0.12–0.72]; P=0.007). CONCLUSIONS:: Intravascular imaging–guided PCI showed clinical benefit over angiography-guided PCI for left main coronary artery disease in reducing the risk of cardiac death, target vessel–related myocardial infarction, or target vessel revascularization. REGISTRATION:: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03381872.