학술논문
A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication
Document Type
Academic Journal
Author
Source
Clinical Genetics. Feb 01, 2002 61(2):152-154
Subject
Language
English
ISSN
0009-9163
Abstract
Kawanishi C, Furuno T, Kishida I, Matsumura T and Kosaka K. A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication Clin Genet 2002: 61: 152–154. © Blackwell Munksgaard, 2002We describe a patient with treatment-resistant schizophrenia who had a duplication in the cytochrome P450IID6 (CYP2D6) gene. This severely ill 71-year-old-woman had responded poorly to several neuroleptics. Molecular genetic study revealed CYP2D6 gene duplication, which results in excessive activity of CYP2D6 that metabolizes various commonly used neuroleptics. The mutation may have contributed to treatment resistance in this case.