학술논문
Evaluating the use of early hormonal therapy in patients with localised or locally advanced prostate cancer
Document Type
Academic Journal
Author
Source
Prostate Cancer and Prostatic Diseases. Jun 01, 2005 8(2):140-151
Subject
Language
English
ISSN
1365-7852
Abstract
This article evaluates the use of early hormonal therapy in patients with localised or locally advanced prostate cancer. In patients receiving radiotherapy, an overall survival benefit is proven for adjuvant goserelin ('Zoladex') in locally advanced disease. Adjuvant to radical prostatectomy, castration (goserelin or orchiectomy) has demonstrated an overall survival benefit in patients with lymph node metastases. Survival advantages have not yet been proven with nonsteroidal antiandrogens, but immediate or adjuvant bicalutamide ('Casodex') improves objective progression-free survival in patients with locally advanced disease, with certain quality-of-life advantages over castration.