학술논문
Campylobacter jejuni 72Dz/92 cjaC gene coding 28 kDa immunopositive protein, a homologue of the solute-binding components of the ABC transport system
Document Type
Academic Journal
Source
Letters in Applied Microbiology. Jan 01, 1998 26(1):69-76
Subject
Language
English
ISSN
0266-8254
Abstract
Screening of the Campylobacter jejuni 72Dz/92 cosmid gene bank enabled identification of the cjaC (Camp. jejuni antigen C) gene encoding a highly immunogenic protein of apparent molecular mass 28 kDa. Gene bank searches indicated significant overall homology of the cjaC gene product, mainly to the Gram-negative periplasmic solute-binding proteins of the ABC transport system which recognize polar amino acids and opines. CjaC protein contains the motif LVAC at the end of the putative 19 amino acid signal sequence, which suggests that it might be a lipoprotein. In the 5′ flanking region of the cjaC gene, two potential promoter regions were observed. The cjaC gene is conserved among some isolates of three serotypes commonly isolated from humans (HL serotypes 1,4,71).