학술논문
Transforming growth factor β1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor α from bovine cartilage
Document Type
Academic Journal
Author
Source
Annals of the Rheumatic Diseases. Feb 01, 2003 62(2):172-174
Subject
Language
English
ISSN
0003-4967
Abstract
Oncostatin M (OSM) in combination with tumour necrosis factor α (TNFα) promotes marked collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases and could be prevented by transforming growth factor β1 (TGFβ1) or insulin-like growth factor 1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGFβ1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against OSM+TNFα induced destruction.