부산대학교 도서관

INTRODUCTION:: Epidemiological studies show an association between preeclampsia and the development of cardiovascular disease. Does an association exist regarding metabolic disease? METHODS:: Women with a discharge diagnosis of preeclampsia from 2009-2015 were identified from our integrated health care system database. We retrospectively collected demographic and cardiovascular risk factor data by chart review on women with preeclampsia and age/race matched controls from the year 2012. We then assessed 7-year follow-up in these cases and controls. A bivariate matched analysis and logistic regression were used to identify associated factors for preeclampsia while adjusting for other variables. RESULTS:: The incidence of preeclampsia within our network in 2012 was 10.4%. At 7-year follow-up, we found that the cases group have an increased incidence of new-onset hypertension (30.7% vs 2.6%, p<.0001), hyperlipidemia (13.1% vs 2.3%, P<.0001) and diabetes (8.5% vs 1.9%, P<.0001) compared to controls. Hypertension, hyperlipidemia and diabetes served as markers of metabolic disease. Follow-up with a PCP occurred in 19.5% of preeclamptic patients and 14.9% of controls. Statistical analysis showed that preeclampsia was an independent risk factor for current hypertension (OR 6.7 [95% CI 3.4-10.8]), hyperlipidemia (OR 6.5 [95% CI 3.5-10.3]) and diabetes (OR 3.8 [95% CI 1.8-8.3]). CONCLUSION:: Our findings support a relationship between preeclampsia and the development of metabolic disease. The diagnosis of preeclampsia serves as an independent predictor for the development of both cardiovascular and metabolic disease. This data highlights the necessity for establishing follow-up guidelines for preeclamptic patients when planning preventative medical interventions as it relates to cardiovascular and metabolic disease.