학술논문
Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity
Document Type
Academic Journal
Author
Fujiwara, T; Ikeda, M; Esumi, K; Fujita, T D; Kono, M; Tokushige, H; Hatoyama, T; Maeda, T; Asai, T; Ogawa, T; Katsumata, T; Sasaki, S; Suzuki, E; Suzuki, M; Hino, F; Fujita, T K; Zaima, H; Shimada, M; Sugawara, T; Tsuzuki, Y; Hashimoto, Y; Hishigaki, H; Horimoto, S; Miyajima, N; Yamamoto, T; Imagawa, K; Sesoko, S; Fujisawa, Y
Source
The Pharmacogenomics Journal. Dec 01, 2007 7(6):395-403
Subject
Language
English
ISSN
1470-269X
Abstract
Aspirin prevents the production of thromboxane A2 (TXA2) by irreversibly inhibiting platelet cyclooxygenase, exhibiting antiplatelet actions. This agent has been reported to prevent relapse in patients with ischemic heart disease or cerebral infarction via this action mechanism. However, there are individual differences in this action, and aspirin is not effective in some patients, which is referred to as 'aspirin resistance'. In this study, we analyzed laboratory aspirin resistance by platelet aggregation in 110 healthy adult Japanese males using 24 single-nucleotide polymorphisms (SNPs) of nine genes involved in platelet aggregation/hemorrhage. Among SNPs involved in platelet aggregation, aspirin was less effective for 924T homozygote of a TXA2 receptor, 924T > C, and 1018C homozygote of a platelet membrane glycoprotein GPIbα, 1018C > T, suggesting that 924T and 1018C alleles are involved in aspirin resistance.